Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats
Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats
复制标题
DOI：
10.1016/j.phymed.2012.11.011
复制
发表时间：
2013-02-15
期刊：
影响因子：
7.9
通讯作者：
Rajesha, J.
中科院分区：
文献类型：
--
作者：
Moree, Sadiq S.;Kavishankar, G. B.;Rajesha, J.
糖尿病是一种以高血糖为特征的慢性代谢紊乱。其并发症，如神经病变、心脏病、肾病以及微血管和大血管疾病，被认为是由于氧化应激增加和抗氧化剂水平下降所致。本研究的目的是测定合成的二异落叶松脂素二葡糖苷(SDG)对链脲佐菌素(STZ)诱导的糖尿病大鼠的降血糖作用。单次给药(20 mg/kg bw.)两天的研究表明，用药后48h血糖水平呈剂量依赖性下降，最大降幅为64.62%(p<；0.05)，与标准药物甲苯丁胺(20 mg/kg bw)相当。在一项为期14天的多剂量研究中，较低剂量的SDG(5和10 mg/kg bw.)表现出血糖水平、血脂水平的适度下降，抗氧化酶的恢复，胰岛素和C-肽水平的提高，这表明分泌胰岛素的β细胞再生。SDG还可使糖尿病大鼠的血脂和酶类抗氧化剂水平恢复到相当高的水平。目前的研究结果表明，糖尿病与氧化应激增加有关，表现为血清丙二醛(MDA)水平的增加，过氧化氢酶(CAT)、超氧化物歧化酶(SOD)和谷胱甘肽(GSH)水平的降低。此外，糖尿病与血清总胆固醇和甘油三酯水平的升高以及胰岛素和C肽水平的下降有关。SDG在延缓糖尿病并发症的发展方面是有效的。我们认为，合成的SDG通过抑制ROS水平介导的酶和非酶类抗氧化剂水平的升高而发挥抗高血糖作用，从而防止肝脏的过氧化损伤。还能维持组织功能，从而提高STZ诱导的糖尿病大鼠靶细胞对胰岛素的敏感性和反应性。(C)2012年爱思唯尔股份有限公司。版权所有。
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia. Its complications such as neuropathy, cardiopathy, nephropathy, and micro and macro vascular diseases are believed to be due to the increase in oxidative stress and decrease in the level of antioxidants. The aim of this study was to determine the antihyperglycemic activity of synthetic Secoisolariciresinol.diglucoside (SDG) in streptozotocin (STZ)-induced diabetic rats. The synthetic SDG in a single-dose (20 mg/kg b.w.) two-day study showed dose-dependent reduction in glucose levels with maximum effect of 64.62% at 48 h post drug treatment (p < 0.05), which is comparable to that of the standard drug tolbutamide (20 mg/kg b.w.). In a multi-dose fourteen-day study, lower doses of SDG (5 and 10 mg/kg b.w.) exhibited moderate reduction in glucose levels, lipid profile, restoration of antioxidant enzymes and improvement of the insulin and c-peptide levels which shows the regeneration of beta-cell which secretes insulin. Altered levels of lipids and enzymatic antioxidants were also restored by the SDG to the considerable levels in diabetic rats.Results of the present investigation suggest that diabetes is associated with an increase in oxidative stress as shown by increase in serum malondialdehyde (MDA), decreased levels of catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH). Also, diabetes is associated with an increase in serum total cholesterol as well as triglycerides levels and decrease in insulin and c-peptide levels.SDG is effective in retarding the development of diabetic complications. We propose that synthetic SDG exerts anti hyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants. And, also maintaining tissue function which results in improving the sensitivity and response of target cells in STZ-induced diabetic rats to insulin. (C) 2012 Elsevier GmbH. All rights reserved.