DNA and Histone Methylation in Gastric Cancer
DNA and Histone Methylation in Gastric Cancer
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DOI：
10.1007/978-3-319-59786-7_13
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
K. Matsusaka;Atsushi Kaneda
中科院分区：
文献类型：
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作者：
K. Matsusaka;Atsushi Kaneda
幽门螺杆菌（Helicobacter pylori，H. pylori）和EB病毒（EBV）。胃癌通常与异常的DNA高甲基化以及遗传改变相关，并且这两种感染因子参与各种分子事件。本章重点介绍胃癌的表观遗传畸变，包括超甲基化及其与两种感染因子的相关性，以及最近报道的组蛋白修饰。
Two unique pathogens play crucial roles in gastric carcinogenesis, namelyHelicobacter pylori(H. pylori) and Epstein-Barr virus (EBV). Gastric cancer is frequently associated with aberrant DNA hypermethylation as well as genetic alterations, and the both these infectious agents are involved in various molecular events. This chapter focuses on epigenetic aberrations in gastric cancer, including hypermethylation and its correlations with the two infectious agents as well as the recently reported histone modifications.