The isoprostanes: Their quantification as an index of oxidant stress status in vivo
The isoprostanes: Their quantification as an index of oxidant stress status in vivo
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DOI：
10.1081/dmr-100102340
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发表时间：
2000-01-01
影响因子：
5.9
通讯作者：
Morrow, JD
中科院分区：
文献类型：
--
作者：
Morrow, JD
F-2异前列烷是一系列独特的类前列腺素化合物，在体内由花生四烯酸的精细自由基催化过氧化反应形成，不依赖于环氧合酶。这篇综述的目的是简要总结我们目前对异前列烷的认识。异前列烷形成的生物化学相关的新方面和这些化合物的分析方法进行了讨论。然后概述了测量F-2异前列烷作为氧化应激动物模型中脂质过氧化反应标志物的效用。最后，提供的例子中，异前列腺素的定量照亮了氧化损伤在几种人类疾病中的作用。
The F-2 isoprostanes are a unique series of prostaglandinlike compounds formed in vivo from the fine-radical-catalyzed peroxidation of arachidonic acid independent of the cyclooxygenase enzyme. The purpose of this review is to briefly summarize the status of our current knowledge regarding the isoprostanes. Novel aspects related to the biochemistry of isoprostane formation and methods by which these compounds are analyzed are discussed. The utility of measuring F-2 isoprostanes as markers of lipid peroxidation in animal models of oxidant stress are then outlined. Finally, examples are provided in which quantification of isoprostanes have illuminated the role of oxidative injury in several human diseases.