Atypical antipsychotics and risk of cerebrovascular accidents
Atypical antipsychotics and risk of cerebrovascular accidents
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DOI：
10.1176/appi.ajp.161.6.1113
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发表时间：
2004-06-01
影响因子：
17.7
通讯作者：
Lanctôt, KL
中科院分区：
文献类型：
--
作者：
Herrmann, N;Mamdani, M;Lanctôt, KL
目的：随机对照试验表明，至少一种非典型抗精神病药物可能与老年痴呆症患者中风风险增加有关。本研究探讨了非典型抗精神病药物的使用和中风之间的关联在elderly.Method：作者进行了一项回顾性的人口为基础的队列研究，患者年龄在66岁以上，通过连接行政卫生保健数据库。三个队列用户典型的抗精神病药物，利培酮，奥氮平-进行了确定和compared.Results：受试者治疗典型的抗精神病药物（N= 1，015）进行了比较，那些给予利培酮（N= 6，964）和奥氮平（N= 3，421）。基于模型的估计调整的协变量假设与中风的风险显示相对风险估计为1.1（95%CI =0.5-2.3）奥氮平和1.4（95%CI =0.7-2.8）为利培酮。结论：奥氮平和利培酮的使用与中风的风险增加相比，典型的抗精神病药物的使用没有统计学意义。
Objective: Randomized controlled trials have suggested that at least one atypical antipsychotic may be associated with an increased risk of stroke in older people with dementia. This study examined the association between atypical antipsychotic use and stroke in the elderly.Method: The authors conducted a retrospective population-based cohort study of patients over the age of 66 by linking administrative health care databases. Three cohorts-users of typical antipsychotics, risperidone, and olanzapine-were identified and compared.Results: Subjects treated with typical antipsychotics (N=1,015) were compared with those given risperidone (N=6,964) and olanzapine (N=3,421). Model-based estimates adjusted for covariates hypothesized to be associated with stroke risk revealed relative risk estimates of 1.1 (95% CI=0.5-2.3) for olanzapine and 1.4 (95% CI=0.7-2.8) for risperidone.Conclusions: Olanzapine and risperidone use were not associated with a statistically significant increased risk of stroke compared with typical antipsychotic use.