Schizophrenia.
Schizophrenia.
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DOI：
10.1016/s0140-6736(15)01121-6
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发表时间：
2016-07-02
期刊：
影响因子：
--
通讯作者：
Mortensen PB
中科院分区：
文献类型：
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作者：
Owen MJ;Sawa A;Mortensen PB
精神分裂症是一种复杂的，异质性的行为和认知综合征，其起源似乎在于大脑发育的遗传和/或环境破坏。多巴胺能神经传递功能障碍似乎有助于精神病症状的发生，但证据也指出，更广泛和可变的参与大脑区域和回路。有新的证据表明，突触功能的干扰可能是神经元连接异常的基础，可能涉及中间神经元，但这些事件的确切性质，位置和时间是不确定的。目前的治疗主要包括服用抗精神病药物，同时进行心理治疗、社会支持和康复，但迫切需要更有效的治疗和更有效地提供服务。近年来，随着基因组学、流行病学和神经科学的进步，对这种疾病的理解取得了很大进展，进一步科学进步的机会很大：但挑战也很大。
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome whose origins appear to lie in genetic and/or environmental disruption of brain development. Dysfunction of dopaminergic neurotransmission appears to contribute to the genesis of psychotic symptoms but the evidence also points to a more widespread and variable involvement of brain areas and circuits. There is emerging evidence that disturbances of synaptic function might underlie abnormalities of neuronal connectivity possibly involving interneurons, but the precise nature, location and timing of these events is uncertain. Current treatment consists largely in the administration of antipsychotic drugs combined with psychological therapies, social support and rehabilitation, but there is a pressing need for more effective treatments and for services to be delivered more effectively. Progress in understanding the disorder has been great in recent years with advances in genomics, epidemiology and neuroscience, and the opportunities for further scientific advance are great: but so are the challenges.