Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis
Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis
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DOI：
10.1136/thorax.55.2.138
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发表时间：
2000-02-01
期刊：
影响因子：
10
通讯作者：
Barnes, PJ
中科院分区：
文献类型：
--
作者：
Antuni, JD;Kharitonov, SA;Barnes, PJ
Background-Non-invasive assessment of inflammation is likely to be useful in the management of cystic fibrosis (CF). Exhaled carbon monoxide (CO) concentrations are increased in patients with clinically stable CE A study was undertaken to determine whether this marker of oxidative damage is further increased during exacerbations of the disease.Methods-Exhaled CO concentrations were measured in 12 healthy non-smoking control subjects (six men) of mean (SE) age 37 (2) years with forced expiratory volume in one second (FEV1) 95 (1)% predicted and in 44 patients with CF (20 men) of mean (SE) age 29 (1) years with FEV1 56 (3)% predicted using an on-line CO analyser.Results-Twenty nine patients were in a stable condition while 15 had clinically defined respiratory exacerbations (increased cough and production of sputum, change in the quality of the sputum, shortness of breath, sensation of chest congestion, and deterioration of FEV1) and represented the unstable group. Exhaled CO concentrations were 2.0 (0.15)ppm in the control group, were increased in the stable CF group to 2.7 (0.13)ppm (differences between means -0.67 (0.22), 95% confidence interval (CI) 0.22 to 1.12, p
