The Role of the Eph Receptor Family in Tumorigenesis.
The Role of the Eph Receptor Family in Tumorigenesis.
复制标题
DOI：
10.3390/cancers13020206
复制
发表时间：
2021-01-08
期刊：
影响因子：
5.2
通讯作者：
Schäfer G
中科院分区：
文献类型：
--
作者：
Anderton M;van der Meulen E;Blumenthal MJ;Schäfer G
Eph受体家族参与肿瘤促进和抑制，这取决于可用受体与配体、衔接蛋白和触发的下游信号传导途径相互作用的组织特异性背景。这种复杂的相互作用不仅对肿瘤发生有影响，而且为开发新的癌症靶向策略提供了基础。这篇综述全面总结了目前的知识Eph受体的影响，在肿瘤发生的组织和受体特异性的方式，目的是开发一个更好的理解Eph信号通路的潜在靶向在新的癌症治疗。Eph受体酪氨酸激酶家族通过与其同源肝配蛋白配体结合而激活，是参与动物发育的信号传导途径的重要组成部分。最近，由于它们参与肿瘤发生，它们受到了极大的关注。在大多数情况下，它们的表达被改变，影响细胞增殖和迁移。根据上下文，Eph受体具有在许多癌症中充当肿瘤促进剂和抑制剂的潜力，所述癌症例如乳腺癌、结肠直肠癌、肺癌、前列腺癌、脑癌和卡波西肉瘤（KS），后者与EphA 2内在相关，因为EphA 2是卡波西肉瘤相关疱疹病毒（KSHV）用于内皮细胞进入的受体。此外，EphA 2失调与KS相关，表明它在这种情况下具有双重作用。已经检测到EphA 2序列变异和KSHV感染/KS进展之间的关联，但需要进一步的工作来正式建立EphA 2信号传导和KS肿瘤发生之间的联系。本文综述了Eph受体家族，特别是EphA 2在肿瘤发生中的作用的现有文献，旨在更好地了解Eph信号通路在新型癌症治疗中的潜在靶向作用。
The Eph receptor family is implicated in both tumour promotion and suppression, depending on the tissue-specific context of available receptor interactions with ligands, adaptor proteins and triggered downstream signalling pathways. This complex interplay has not only consequences for tumorigenesis but also offers a basis from which new cancer-targeting strategies can be developed. This review comprehensively summarises the current knowledge of Eph receptor implications in oncogenesis in a tissue- and receptor-specific manner, with the aim to develop a better understanding of Eph signalling pathways for potential targeting in novel cancer therapies. The Eph receptor tyrosine kinase family, activated by binding to their cognate ephrin ligands, are important components of signalling pathways involved in animal development. More recently, they have received significant interest due to their involvement in oncogenesis. In most cases, their expression is altered, affecting the likes of cell proliferation and migration. Depending on the context, Eph receptors have the potential to act as both tumour promoters and suppressors in a number of cancers, such as breast cancer, colorectal cancer, lung cancer, prostate cancer, brain cancer and Kaposi’s sarcoma (KS), the latter being intrinsically linked to EphA2 as this is the receptor used for endothelial cell entry by the Kaposi’s sarcoma-associated herpesvirus (KSHV). In addition, EphA2 deregulation is associated with KS, indicating that it has a dual role in this case. Associations between EphA2 sequence variation and KSHV infection/KS progression have been detected, but further work is required to formally establish the links between EphA2 signalling and KS oncogenesis. This review consolidates the available literature of the role of the Eph receptor family, and particularly EphA2, in tumorigenesis, with the aim to develop a better understanding of Eph signalling pathways for potential targeting in novel cancer therapies.
登录
查看更多内容
影响因子：
5.8
作者：
Bhatia S;Hirsch K;Bukkapatnam S;Baig NA;Oweida A;Griego A;Calame D;Sharma J;Donson A;Foreman N;Albanese C;Venkataraman S;Vibhakar R;Karam SD
通讯作者：
Karam SD
DOI：
10.1073/pnas.1119592109
发表时间：
2012-05-08
影响因子：
11.1
作者：
Chakraborty, Sayan;Veettil, Mohanan Valiya;Chandran, Bala
通讯作者：
Chandran, Bala
影响因子：
50.3
作者：
Binda E;Visioli A;Giani F;Lamorte G;Copetti M;Pitter KL;Huse JT;Cajola L;Zanetti N;DiMeco F;De Filippis L;Mangiola A;Maira G;Anile C;De Bonis P;Reynolds BA;Pasquale EB;Vescovi AL
通讯作者：
Vescovi AL
影响因子：
--
作者：
Bhatia S;Baig NA;Timofeeva O;Pasquale EB;Hirsch K;MacDonald TJ;Dritschilo A;Lee YC;Henkemeyer M;Rood B;Jung M;Wang XJ;Kool M;Rodriguez O;Albanese C;Karam SD
通讯作者：
Karam SD
影响因子：
3.7
作者：
Ferguson BD;Liu R;Rolle CE;Tan YH;Krasnoperov V;Kanteti R;Tretiakova MS;Cervantes GM;Hasina R;Hseu RD;Iafrate AJ;Karrison T;Ferguson MK;Husain AN;Faoro L;Vokes EE;Gill PS;Salgia R
通讯作者：
Salgia R