Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches
Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches
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DOI：
10.1038/s41598-020-58822-w
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发表时间：
2020-02-06
影响因子：
4.6
通讯作者：
Lim, Eunju
中科院分区：
文献类型：
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作者：
Bok, Moonjeong;Zhao, Zhi-Jun;Lim, Eunju
开发了一种由透明质酸微针组成的多功能系统，作为快速局部递送的有效透皮递送平台。微针可以通过控制透明质酸溶液的浓度来调节尖端的填充量。超声通过声压振动诱导HA微针溶解，AC离子导入改善了HA离子和罗丹明B的静电力驱动的扩散。使用明胶水凝胶在体外分析了超声对罗丹明释放的影响。实验还评估了交流对离子感应转移的频率和电压依赖性。结果表明，材料的渗透性是材料的关键性能。基于微针中的超声处理和离子电渗疗法的递送系统增加了渗透，从而导致比基于单独的被动或超声处理的递送系统所需的初始递送时间更短的初始递送时间。这项研究突出了超声波和离子导入之间的组合，以提高微针的效率，通过缩短反应时间的意义。我们预计，这一系统可以扩展到大分子和依赖性交付，基于药物的响应时间。
A multifunctional system comprised of hyaluronic acid microneedles was developed as an effective transdermal delivery platform for rapid local delivery. The microneedles can regulate the filling amount on the tip, by controlling the concentration of hyaluronic acid solution. Ultrasonication induces dissolution of the HA microneedles via vibration of acoustic pressure, and AC iontophoresis improves the electrostatic force-driven diffusion of HA ions and rhodamine B. The effect of ultrasound on rhodamine release was analyzed in vitro using a gelatin hydrogel. The frequency and voltage dependence of the AC on the ion induction transfer was also evaluated experimentally. The results showed that the permeability of the material acts as a key material property. The delivery system based on ultrasonication and iontophoresis in microneedles increases permeation, thus resulting in shorter initial delivery time than that required by delivery systems based on passive or ultrasonication alone. This study highlights the significance of the combination between ultrasonic waves and iontophoresis for improving the efficiency of the microneedles, by shortening the reaction duration. We anticipate that this system can be extended to macromolecular and dependence delivery, based on drug response time.