Assessment of Nutritional Status in Cancer - The Relationship Between Body Composition and Pharmacokinetics
Assessment of Nutritional Status in Cancer - The Relationship Between Body Composition and Pharmacokinetics
复制标题
DOI：
10.2174/18715206113139990322
复制
发表时间：
2013-10-01
影响因子：
2.8
通讯作者：
Baracos, Vickie E.
中科院分区：
文献类型：
--
作者：
Prado, Carla M. M.;Maia, Yara L. M.;Baracos, Vickie E.
几种营养评估工具已用于肿瘤学环境中，以监测营养状况及其相关的预后意义。身体成分是评估营养状况的基础。最近，使用准确和精确的身体组成工具，显着增加了营养评估的价值，在这种临床环境。计算机断层扫描（CT）是提供身体组成的最新评估的技术的一个例子。随着CT图像的使用，即使在具有相同体重或体重指数的人中，癌症患者的身体组成也存在很大的差异。严重肌肉耗竭（肌肉减少症）已成为一种普遍的身体组成表型，可预测功能状态差、肿瘤进展时间较短、生存期较短和剂量限制性毒性发生率较高。癌症患者身体组成的变异性可能是细胞毒性药物代谢差异的来源。未来的临床试验研究减少肌肉减少症患者的剂量，以及基于治疗前身体成分评估的剂量递增研究有可能改变癌症治疗模式。
Several nutritional assessment tools have been used in oncology settings to monitor nutritional status and its associated prognostic significance. Body composition is fundamental for the assessment of nutritional status. Recently, the use of accurate and precise body composition tools has significantly added to the value of nutritional assessment in this clinical setting. Computerized tomography (CT) is an example of a technique which provides state-of-the-art assessment of body composition. With use of CT images, a great variability in body composition of cancer patients has been identified even in people with identical body weight or body mass index. Severe muscle depletion (sarcopenia) has emerged as a prevalent body composition phenotype which is predictive of poor functional status, shorter time to tumor progression, shorter survival, and higher incidence of dose-limiting toxicity. Variability in body composition of cancer patients may be a source of disparities in the metabolism of cytotoxic agents. Future clinical trials investigating dose reductions in patients with sarcopenia and dose-escalating studies based on pre-treatment body composition assessment have the potential to alter cancer treatment paradigms.