PET [11C]DASB imaging of serotonin transporters in patients with alcoholism
PET [11C]DASB imaging of serotonin transporters in patients with alcoholism
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DOI：
10.1111/j.1530-0277.2006.00261.x
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Innis, Robert B.
中科院分区：
文献类型：
--
作者：
Brown, Amira K.;George, David T.;Innis, Robert B.
目的：酗酒和攻击行为均与神经化学测量结果有关，表明血清素突触传递减少。我们测量了中等规模的酗酒患者样本中血清素转运蛋白 (SERT) 的密度，并评估了这些患者的攻击性特征。方法：30 名酒精住院患者和 18 名健康对照接受了 [C-11]-3-氨基-4-(2-二甲基氨基甲基苯硫基)-苯甲腈的 PET 扫描。根据 Buss-Durkee 敌意指数前三分之一和后三分之一分数之间的比较，将酗酒住院患者分为攻击性或非攻击性。 结果：使用逐像素比较，3 组受试者（攻击性酒精受试者、非攻击性酒精受试者和健康对照）之间或酒精组和健康对照之间，没有任何大脑区域显示 SERT 结合发生显着变化。没有任何临床测量（包括攻击性测量）与酗酒者的 SERT 结合相关。结论：与之前使用非选择性配体 [I-123]beta-CIT 的成像报告相反，我们发现酗酒者的 SERT 密度没有显着变化。
Objective: Alcoholism and aggression have each been associated with neurochemical measurements suggestive of decreased serotonin synaptic transmission. We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics.Methods: Thirty alcoholic inpatients and 18 healthy controls received a PET scan with [C-11]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile. The alcoholic inpatients were classified as aggressive or nonaggressive based on a comparison between the top third and bottom third scores on the Buss - Durkee Hostility Index.Results: Using a pixel-wise comparison, no brain region showed significant alterations in SERT binding among the 3 groups of subjects (aggressive alcoholic subjects, nonaggressive alcoholic subjects, and healthy controls) or between the combined alcoholic group and healthy controls. None of the clinical measures (including measures of aggression) correlated with SERT binding in the alcoholic subjects.Conclusion: Contrary to prior imaging reports using the nonselective ligand [I-123]beta-CIT, we found no significant alterations of SERT density in alcoholic patients.