Size at birth and risk of breast cancer: update from a prospective population-based study.
Size at birth and risk of breast cancer: update from a prospective population-based study.
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出生时的体型和患乳腺癌的风险：一项基于人群的前瞻性研究的更新。
DOI：
10.1007/s10654-015-0045-2
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发表时间：
2015
影响因子：
13.6
通讯作者：
Vatten,LarsJohan
中科院分区：
文献类型：
--
作者：
Sandvei,MarieSøfteland;Lagiou,Pagona;Romundstad,PålRichard;Trichopoulos,Dimitrios;Vatten,LarsJohan
出生尺寸变量(出生体重、出生长度和头围)已被报道与成人乳腺癌风险呈正相关，而胎盘重量可能的关联尚未得到充分研究。也有人提出，母亲的身高可能会改变出生大小与成人乳腺癌风险的关系，但这一点尚未得到详细研究。我们更新了对22,931名挪威女性的长期随访(平均51年的随访期间，870名女性被诊断患有乳腺癌)，并评估了胎盘重量与乳腺癌风险的关系，此外，我们还提供了与出生体重、出生长度和头围相关的乳腺癌风险的最新分析。胎盘重量与成年后患乳腺癌的风险无关，但与出生长度呈正相关(HR 1.13，95%CI 1.05~1.21，每增加2厘米)，但与出生体重无关(HR 1.02，95%CI 0.95~1.10，每增加0.5公斤)。在出生长度方面，母亲相对较高的女性的风险分级增加尤其明显(Pfor Trend，0.001)，而母亲相对较矮的女性的趋势(Pfor Trend，0.221)。结果表明，出生长度与乳腺癌风险之间存在着强有力的正相关关系，在母亲相对较高的女性中，这种关联可能尤其强烈。我们发现胎盘重量与患乳腺癌的风险无关。
Birth size variables (birth weight, birth length and head circumference) have been reported to be positively associated with adult breast cancer risk, whereas a possible association of placental weight has not been adequately studied. It has also been suggested that maternal height may modify the association of birth size with adult breast cancer risk, but this has not been studied in detail. We updated a long-term follow-up of 22,931 Norwegian women (average of 51 years of follow up during which 870 women were diagnosed with breast cancer) and assessed placental weight in relation to breast cancer risk, in addition to providing updated analyses on breast cancer risk in relation to birth weight, birth length and head circumference. Placental weight was not associated with risk for breast cancer in adulthood, but there was a positive association of breast cancer risk with birth length (HR 1.13, 95 % CI 1.05–1.21, per 2 cm increment), though not with birth weight (HR 1.02, 95 % CI 0.95–1.10 per 0.5 kg increment). For birth length, the graded increase in risk was particularly strong among women whose mothers were relatively tall (pfor trend, 0.001), compared to the trend among women whose mothers were relatively short (pfor trend, 0.221). The results showed a robust and positive association of birth length with breast cancer risk, and may be especially strong in women whose mothers were relatively tall. We found no association of placental weight with risk for breast cancer.