Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence.
Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence.
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DOI：
10.1017/s0954579418000330
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发表时间：
2018-08
影响因子：
3.3
通讯作者：
Roberts S
中科院分区：
文献类型：
--
作者：
Barker ED;Cecil CAM;Walton E;Houtepen LC;O'Connor TG;Danese A;Jaffee SR;Jensen SKG;Pariante C;McArdle W;Gaunt TR;Relton CL;Roberts S
在来自纵向流行病学出生队列的785对母子（50%为男性）中，我们调查了炎症相关表观遗传多基因风险评分（i-ePGS）、环境暴露、认知功能以及儿童和青少年内化和外化问题之间的关系。我们检查了产前和产后的影响。对于外化问题，一种产前效应被发现：出生时的i-ePGS与较高的外化问题（7-15岁）间接相关，通过较低的认知功能（7岁）。对于内化问题，我们确定了两种影响。对于产前影响，出生时的i-ePGS通过7岁时i-ePGS的连续性与较高的内化症状相关。对于出生后的影响，通过较高的i-ePGS（7岁），较高的出生逆境暴露（出生至7岁）与较高的内化问题（7-15岁）相关。因此，外化问题主要与涉及较低认知功能的产前影响有关，而内化问题似乎与产前和产后影响有关。目前的研究支持i-ePGS与儿童和青少年心理健康之间的联系。
In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function and child and adolescent internalising and externalising problems. We examined prenatal and postnatal effects. For externalising problems, one prenatal effect was found: i-ePGS at birth associated with higher externalising problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalising problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalising symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalising problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalising problems were related mainly to prenatal effects involving lower cognitive function, whereas internalising problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.