Pathophysiological Role of S-Nitrosylation and Transnitrosylation Depending on S-Nitrosoglutathione Levels Regulated by S-Nitrosoglutathione Reductase.
Pathophysiological Role of S-Nitrosylation and Transnitrosylation Depending on S-Nitrosoglutathione Levels Regulated by S-Nitrosoglutathione Reductase.
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DOI：
10.4062/biomolther.2018.179
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发表时间：
2018-11-01
影响因子：
3.7
通讯作者：
Choi MS
中科院分区：
文献类型：
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作者：
Choi MS
一氧化氮（NO）介导多种生理和病理过程，包括细胞增殖、分化和炎症。蛋白质s -亚硝基化（SNO）是一种no介导的可逆蛋白质修饰，可导致靶蛋白活性和功能的改变。最近关于蛋白质-蛋白质转亚硝基化反应（NO基团从一种蛋白质转移到另一种蛋白质）的研究发现揭示了NO调节特定信号通路的机制。细胞内s -亚硝基谷胱甘肽（GSNO）水平受GSNO还原酶（GSNOR）控制，GSNO还原酶是NO/SNO信号的主要调节因子。越来越多的gsnr相关研究表明，脱硝基化在细胞NO/SNO稳态和人体病理生理中起着重要作用。本文综述了gsno介导的NO/SNO信号通路依赖于GSNOR表达或活性的最新证据。此外，本文还将讨论GSNOR作为药物治疗靶点的适用性。
Nitric oxide (NO) mediates various physiological and pathological processes, including cell proliferation, differentiation, and inflammation. Protein S-nitrosylation (SNO), a NO-mediated reversible protein modification, leads to changes in the activity and function of target proteins. Recent findings on protein-protein transnitrosylation reactions (transfer of an NO group from one protein to another) have unveiled the mechanism of NO modulation of specific signaling pathways. The intracellular level of S-nitrosoglutathione (GSNO), a major reactive NO species, is controlled by GSNO reductase (GSNOR), a major regulator of NO/SNO signaling. Increasing number of GSNOR-related studies have shown the important role that denitrosylation plays in cellular NO/SNO homeostasis and human pathophysiology. This review introduces recent evidence of GSNO-mediated NO/SNO signaling depending on GSNOR expression or activity. In addition, the applicability of GSNOR as a target for drug therapy will be discussed in this review.