Ambulatory treatment of lead poisoning: report of 1,155 cases.
Ambulatory treatment of lead poisoning: report of 1,155 cases.
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铅中毒的门诊治疗：1,155 例报告。
DOI：
10.1542/peds.46.3.389
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发表时间：
1970
期刊：
影响因子：
8
通讯作者：
M. J. O'Connell
中科院分区：
文献类型：
--
作者：
H. Sachs;L. A. Blanksma;E. F. Murray;M. J. O'Connell
将铅浓度大于50 µg/100 ml全血的受试者转诊至市铅中毒诊所进行评估。当两个血铅水平超过50 µg时，给予螯合剂，或在随后的8小时内，依地酸钙二钠（EDTA）激发试验产生尿铅超过1，000 µg/l。治疗是在门诊基础上进行的。中度脑病患者住院治疗。在1967年和1968年，分别有582名和573名患者接受了EDTA肌肉注射、口服青霉胺或两种药物顺序给药。在1,155名患者中，103名或8.9%的患者存在铅中毒的临床证据。观察到对青霉胺的几种药物反应，但没有对EDTA的反应，由于铅中毒亚临床病例的早期发现和解毒，死亡率下降。
Subjects with lead concentrations greater than 50 µg per 100 ml whole blood were referred to a municipal lead poisoning clinic for evaluation. Chelating agents were administered when two blood lead levels were more than 50 µg, or calcium disodium edetate (EDTA) provocative test yielded over 1,000 µg/l of lead in the urine in the succeeding 8 hours. Therapy was on an ambulatory basis. Patients with moderate encephalopathy were hospitalized. Intramuscular EDTA, oral penicillamine, or the two drugs in sequence were given to 582 patients in 1967 and to 573 patients in 1968. Clinical evidence of lead intoxication was present in 103 or 8.9% of the 1,155 patients. Several drug reactions to penicillamine were observed, but none to EDTA, and mortality dropped due to early detection and detoxification of subclinical cases of lead poisoning.