Effect of paternal overweight or obesity on IVF treatment outcomes and the possible mechanisms involved.
Effect of paternal overweight or obesity on IVF treatment outcomes and the possible mechanisms involved.
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父亲超重或肥胖对IVF治疗结果的影响及其可能机制
DOI：
10.1038/srep29787
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发表时间：
2016-07-14
影响因子：
4.6
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Yang Q;Zhao F;Hu L;Bai R;Zhang N;Yao G;Sun Y
与正常体重的人相比，肥胖者的白细胞端粒长度（LTL）较短。然而，目前尚不清楚精子端粒长度（STL）是否与肥胖有关。该研究的目的是评估男性体重指数（BMI）对接受IVF的夫妇的STL，胚胎质量和临床结局的影响。总共招募了651对夫妇，包括345名BMI正常的男性和306名BMI超重的男性（正常BMI组：20-25 kg/m2;超重BMI组：>28 kg/m2）。研究发现，男性BMI> 28 kg/m2的夫妇与BMI正常的夫妇相比，受精率、优质胚胎率和临床妊娠率显著降低。超重BMI组的平均STL也明显短于正常BMI组。结果还表明，与正常BMI个体相比，BMI较高的个体具有较高的ROS（活性氧）含量和精子DNA片段化率。超重BMI组的线粒体活性也低于正常BMI组。这是第一份发现超重/肥胖男性的STL较短的报告，这可能是他们在IVF周期中治疗结果较差的原因。
Leukocyte telomere lengths (LTLs) are shorter in obese compared with normal weight people. However, it is not known whether sperm telomere length (STL) is related to obesity. The aim of the study was to evaluate the impact of men’s body mass index (BMI) on STL, embryo quality, and clinical outcomes in couples undergoing IVF. In total, 651 couples were recruited, including 345 men with a normal BMI and 306 men with an overweight BMI (normal BMI group: 20–25 kg/m2; overweight BMI group: >28 kg/m2). We found that couples with male’s BMI over 28 kg/m2 exhibited a significantly lower fertilization rate, good-quality embryo rate and clinical pregnancy rate compared to their normal BMI counterparts. The mean STL in the overweight BMI group was also significantly shorter than that of the normal BMI group. The results also showed that individuals with higher BMI had higher ROS (Reactive oxygen species) content and sperm DNA fragmentation rate when compared with normal BMI individuals. Mitochondrial activity was also lower in the overweight BMI group than in the normal BMI group. This is the first report to find that STL is shorter in overweight/obese men, which may account for their poorer treatment outcomes in IVF cycles.