EFFECT OF BRONCHOPULMONARY LAVAGE ON LUNG RETENTION AND CLEARANCE OF PARTICULATE MATERIAL IN HAMSTERS
EFFECT OF BRONCHOPULMONARY LAVAGE ON LUNG RETENTION AND CLEARANCE OF PARTICULATE MATERIAL IN HAMSTERS
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DOI：
10.2307/3431355
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发表时间：
1992-07-01
影响因子：
10.4
通讯作者：
MOODY, JC
中科院分区：
文献类型：
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作者：
ELLENDER, M;HODGSON, A;MOODY, JC
将仓鼠暴露于用Co-57标记的熔融铝硅酸盐颗粒（FAP）的气溶胶中。从暴露后1周、1个月或6个月开始，对三组动物进行支气管肺泡灌洗。在25天的时间内，每个治疗组灌洗8次。每次灌洗包括10次盐水肺冲洗。对于每组，灌洗治疗开始时约60-70%的Co-57体内含量被去除;其中近一半在前两次灌洗中被回收。巨噬细胞含量和Co-57活性之间呈正相关。灌洗动物的钴-57随后的部分清除率与未处理的对照组动物无显著差异。
Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with Co-57. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 saline washes of the lungs. For each group, about 60-70% of the body content of Co-57 at the start of lavage treatment was removed; nearly half of this was recovered in the first two lavages. A positive correlation was demonstrated between the macrophage content and Co-57 activity of the washings. The subsequent fractional clearance rate of Co-57 from lavaged animals was not significantly different from that in a group of untreated control animals.