Propolis Improves Periodontal Status and Glycemic Control in Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial
Propolis Improves Periodontal Status and Glycemic Control in Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial
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DOI：
10.1902/jop.2016.150694
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发表时间：
2016-12-01
影响因子：
4.3
通讯作者：
Van Dyke, Thomas E.
中科院分区：
文献类型：
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作者：
El-Sharkawy, Hesham M.;Anees, Mohamed M.;Van Dyke, Thomas E.
背景：蜂胶是一种由蜜蜂从各种植物来源制成的天然树脂，具有抗菌、抗炎、免疫调节、抗氧化和抗糖尿病等特性。本研究的目的是评估蜂胶补充剂在慢性牙周炎(CP)和2型糖尿病(DMt2)患者中的辅助疗效。方法：对长期存在的慢性牙周炎(CP)和2型糖尿病(DMt2)患者进行为期6个月的掩蔽随机临床试验，比较SRP和安慰剂(安慰剂+SRP组，n=26)或SRP与口服蜂胶400 mg/d的6个月方案(蜂胶+SRP组，n=24)。结果：治疗3个月和6个月后，蜂胶组HbA1c平均水平分别下降0.82%和0.96%单位(P<；0.01)，而安慰剂组差异无统计学意义(P<；0.01)。同样，蜂胶组的空腹血糖和慢性粒细胞白血病水平显著降低，但安慰剂组没有。治疗后两组CP牙周参数均有明显改善。在3个月和6个月后，蜂胶组的探诊深度减少和临床附着水平的增加明显高于对照组。结论：每天一次400 mg的6个月方案是SRP的潜在可行辅助方案，显著降低HbA1c、FPG和CML水平，并改善患有DMt2和CP的患者的牙周治疗结果。
Background: Propolis is a natural resin made by bees from various plant sources and exerts antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and antidiabetic properties. The purpose of this study is to assess adjunctive benefit of propolis supplementation in individuals with chronic periodontitis (CP) and type 2 diabetes mellitus (DMt2) receiving scaling and root planing (SRP).Methods: A 6-month masked, randomized clinical trial comparing SRP with placebo (placebo + SRP group, n = 26) or SRP combined with a 6-month regimen of 400 mg oral propolis once daily (propolis + SRP group, n = 24) was performed in patients with long-standing DMt2 and CP. Treatment outcomes included changes in hemoglobin (Hb) A1c (primary outcome), fasting plasma glucose (FPG), serum N-(sic)-(carboxymethyl) lysine (CML), and periodontal parameters (secondary outcomes).Results: After 3 and 6 months, average HbA1c levels in the propolis group decreased significantly by 0.82% and 0.96% units, respectively (P < 0.01); however, there were no significant differences in the placebo group. Likewise, FPG and CML levels were significantly reduced in the propolis group, but not in the placebo group. After therapy, periodontal parameters of CP were significantly improved in both groups. The propolis group showed significantly greater probing depth reduction and clinical attachment level gain than the control group after 3 and 6 months.Conclusion: A 6-month regimen of 400 mg propolis once daily is a potentially viable adjunct to SRP that significantly reduces levels of HbA1c, FPG, and CML, and improves periodontal therapy outcome in people with DMt2 and CP.