Implantation of dihydrotestosterone propionate into the lateral septum inhibits sexual receptivity in estrogen-primed, ovariectomized rats.
Implantation of dihydrotestosterone propionate into the lateral septum inhibits sexual receptivity in estrogen-primed, ovariectomized rats.
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将丙酸二氢睾酮植入侧隔膜可抑制雌激素引发的卵巢切除大鼠的性接受能力。
DOI：
10.1159/000123323
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发表时间：
1982
影响因子：
4.1
通讯作者：
Baum,MJ
中科院分区：
文献类型：
--
作者：
Tobet,SA;Baum,MJ
进行了两个实验，以确定在雌性大鼠脑中的双氢睾酮的作用，以抑制雌二醇诱导的女性性行为的网站。将含有结晶丙酸二氢睾酮（DHTP）或胆固醇的27号插管单侧植入外侧隔、视前区-下丘脑前区、下丘脑腹内侧核或尾壳核。在实验1中，大鼠在每天注射苯甲酸雌二醇（EB; 0.5 µg/100 g体重）之前接受类固醇的立体定位植入，并测试性感受性。在实验2中，每天给动物注射EB（0.9 μg/100 g体重），并在立体定位植入类固醇之前和之后测试性感受性。在这两个实验中，前凸行为的显着减少，只有获得与侧隔植入DHTP。
Two experiments were conducted to identify sites in the female rat brain at which dihydrotestosterone acts to inhibit estradiol-induced feminine sexual behavior. 27 gauge cannulae containing either crystalline dihydrotestosterone propionate (DHTP) or cholesterol were implanted unilaterally into the lateral septum, preoptic area-anterior hypothalamic area, ventromedial nucleus of the hypothalamus or caudate putamen. In experiment 1, rats were given stereotaxic implants of steroids prior to being injected daily with estradiol benzoate (EB; 0.5 µg/100 g body weight) and tested for sexual receptivity. In experiment 2, animals were injected daily with EB (0.9 µg/100 g body weight) and tested for sexual receptivity prior to and after stereotaxic implantation of steroids. In both experiments significant reductions in lordotic behavior were obtained only with lateral septal implants of DHTP.