Evidence for the activation of the N-methyl-D-aspartate receptor during epileptiform discharge.
Evidence for the activation of the N-methyl-D-aspartate receptor during epileptiform discharge.
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癫痫样放电期间 N-甲基-D-天冬氨酸受体激活的证据。
DOI：
10.1007/978-1-4684-7971-3_35
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发表时间：
1986
影响因子：
--
通讯作者：
Dingledine,R
中科院分区：
文献类型：
--
作者：
King,GL;Dingledine,R
N-methyl-D-aspartate (NMDA) receptors appear to be the most easily characterized class of excitatory amino acid receptors in the central nervous system. Receptor activation by NMDA is blocked by certain phosphonate compounds and is sensitive to the extracellular Mg2+concentration, characteristics lacking in ’non-NMDA’ receptors such as for quisqualate and kainate (for review, see Watkins, 1984). Although NMDA receptors are abundant in the hippocampus (Monaghan et al., 1983; Greenamyre et.al., 1985), putative NMDA antagonists have little or no effect on excitatory synaptic transmission in this structure under normal conditions (see Coan and Collingridge, 1985). Several investigators have therefore suggested that NMDA receptors are activated under abnormal or unusual conditions (Harris et al., 1984; Coan and Collingridge, 1985; Crunelli et al., 1985). For example, NMDA antagonists prevent long-term potentiation (Collingridge et al., 1983b), protect against CNS ischemia (Simon et al., 1984) and suppress some seizures (for review, see Meldrum, 1984). In addition, iontophoretic application of NMDA onto either mammalian neocortical or caudate neurons produces a pattern of burst discharge similar to that observed in an epileptic focus (Flatman et al., 1983; Herrling et al., 1983).
