Functional neuroimaging of speech perception in six normal and two aphasic subjects
Functional neuroimaging of speech perception in six normal and two aphasic subjects
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DOI：
10.1121/1.427068
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发表时间：
1999-07-01
影响因子：
2.4
通讯作者：
Wise, RJS
中科院分区：
文献类型：
--
作者：
Mummery, CJ;Ashburner, J;Wise, RJS
这项正电子发射断层扫描研究采用了相关设计，以调查在六个正常人和两个失语症患者的言语知觉神经活动。正常受试者要么听语音，要么听与信号相关的噪音等价物;后者是非语音刺激，在复杂性上类似于语音，但不被认为是语音。两种类型的刺激的听觉处理共同的区域从那些特定的口语单词分离。言语和非言语呈现率的增加与双侧横回和邻近的上级颞叶皮层的大脑活动相关。特定的语音刺激的相关性位于更靠前的两个上级颞沟。正常受试者中唯一的不对称是后上级颞沟对语言的左侧反应，这与受试者磁共振图像上的结构不对称密切相关。两名患者，谁留下了颞梗死，但表现良好的单个单词的理解任务，也进行了扫描，而听讲话。这些病例显示右侧上级颞叶活动与听力语言的增加率相关，但没有显着的左颞叶激活。这些结果表明，两个半球的背外侧颞叶皮层都参与了言语的词汇前加工。(C)1999年美国声学学会。[S0001-4966（99）00107-1]。
This positron emission tomography study used a correlational design to investigate neural activity during speech perception in six normal subjects and two aphasic patients. The normal subjects listened either to speech or to signal-correlated noise equivalents; the latter were nonspeech stimuli, similar to speech in complexity but not perceived as speechlike. Regions common to the auditory processing of both types of stimuli were dissociated from those specific to spoken words. Increasing rates of presentation of both speech and nonspeech correlated with cerebral activity in bilateral transverse gyri and adjacent superior temporal cortex. Correlations specific to speech stimuli were located more anteriorly in both superior temporal sulci. The only asymmetry in normal subjects was a left lateralized response to speech in the posterior superior temporal sulcus, corresponding closely to structural asymmetry on the subjects' magnetic resonance images. Two patients, who had left temporal infarction but performed well on single word comprehension tasks, were also scanned while listening to speech. These cases showed right superior temporal activity correlating with increasing rates of hearing speech, but no significant left temporal activation. These findings together suggest that the dorsolateral temporal cortex of both hemispheres can be involved in prelexical processing of speech. (C) 1999 Acoustical Society of America. [S0001-4966(99)00107-1].