The effect of iodine uptake on radiation dose absorbed by patient tissues in contrast enhanced CT imaging: Implications for CT dosimetry
The effect of iodine uptake on radiation dose absorbed by patient tissues in contrast enhanced CT imaging: Implications for CT dosimetry
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DOI：
10.1007/s00330-017-4970-1
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发表时间：
2018-01-01
影响因子：
5.9
通讯作者：
Damilakis, John
中科院分区：
文献类型：
--
作者：
Perisinakis, Kostas;Tzedakis, Antonis;Damilakis, John
目的 研究碘摄取对 CT 照射引起的组织/器官吸收剂量的影响及其在 CT 剂量测定中的意义。在 120 例涉及非增强和增强 CT 成像的 CT 检查中回顾性确定了几种放射敏感组织的对比剂引起的 CT 数增加。获得了含有不同碘浓度水溶液的模型的 CT 图像。绘制了 CT 数增加与碘浓度的关系图。通过将记录的 CT 数增加归因于一定浓度的碘水溶液，对临床发生的碘组织摄取进行量化。临床上发生的碘摄取以数学拟人模型表示。使用蒙特卡罗方法模拟标准 120 kV CT 暴露，得出非增强和碘对比增强 CT 成像的器官剂量。发现所研究组织的对比增强 CT 成像期间的平均碘摄取范围为 0.02-0.46% w/w，而记录的最大值为 0.82% w/w。对于相同的 CT 照射，含碘组织比未含碘组织接受更高的辐射剂量，对于高碘摄取的组织，剂量增加超过 100%。使用含碘造影剂显着增加 CT 照射对组织的辐射剂量。非增强、对比增强 CT 可能会向患者组织提供更高的剂量。对比增强 CT 成像的欧洲标准 CT 剂量测定应遇到组织碘摄取。
To investigate the effect of iodine uptake on tissue/organ absorbed doses from CT exposure and its implications in CT dosimetry.The contrast-induced CT number increase of several radiosensitive tissues was retrospectively determined in 120 CT examinations involving both non-enhanced and contrast-enhanced CT imaging. CT images of a phantom containing aqueous solutions of varying iodine concentration were obtained. Plots of the CT number increase against iodine concentration were produced. The clinically occurring iodine tissue uptake was quantified by attributing recorded CT number increase to a certain concentration of aqueous iodine solution. Clinically occurring iodine uptake was represented in mathematical anthropomorphic phantoms. Standard 120 kV CT exposures were simulated using Monte Carlo methods and resulting organ doses were derived for non-enhanced and iodine contrast-enhanced CT imaging.The mean iodine uptake range during contrast-enhanced CT imaging was found to be 0.02-0.46% w/w for the investigated tissues, while the maximum value recorded was 0.82% w/w. For the same CT exposure, iodinated tissues were found to receive higher radiation dose than non-iodinated tissues, with dose increase exceeding 100% for tissues with high iodine uptake.Administration of iodinated contrast medium considerably increases radiation dose to tissues from CT exposure.aEuro cent Radiation absorption ability of organs/tissues is considerably affected by iodine uptakeaEuro cent Iodinated organ/tissues may absorb up to 100 % higher radiation doseaEuro cent Compared to non-enhanced, contrast-enhanced CT may deliver higher dose to patient tissuesaEuro cent CT dosimetry of contrast-enhanced CT imaging should encounter tissue iodine uptake.