Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation
Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation
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DOI：
10.3892/or_00000768
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发表时间：
2010-05-01
期刊：
影响因子：
4.2
通讯作者：
Doki, Yuichiro
中科院分区：
文献类型：
--
作者：
Miyata, Hiroshi;Yamasaki, Makoto;Doki, Yuichiro
深侵（T3-T4）食管癌患者通常接受放化疗伴或不伴手术。然而，治疗前和治疗后淋巴结（LN）状态的预后意义尚不清楚。我们研究了195例深侵食管癌（T3-4, N0-1， MO）接受放化疗的患者。其中，105名患者接受了手术治疗，90名患者仅接受了放化疗。在105例手术治疗的患者中，cN0患者的总生存率明显优于cN1患者（3年生存率，65.3 vs. 25.8%， P=0.0014）。在90名单独接受放化疗的患者中也观察到类似的差异。无LN阳性、1 LN阳性和2-4 LN阳性患者的生存率差异显著(3年生存率，57.1 vs 40.5 vs 17.6%， P
Patients with deeply invading (T3-T4) oesophageal cancers usually receive chemoradiotherapy with or without surgery. However, the prognostic significance of pre-therapy and post-therapy lymph node (LN) status remains unclear. We studied 195 patients who received chemoradiotherapy for deeply invading oesophageal cancers (T3-4, N0-1, MO). Of these, 105 patients underwent surgery while 90 were treated by chemoradiotherapy alone. Of the 105 surgically treated patients, overall survival was significantly better in cN0 patients than in cN1 (3-year survival rate, 65.3 vs. 25.8%, P=0.0014). This difference was similarly observed in 90 patients who received chemoradiotherapy alone. Patient survival differed significantly among patients with no positive LN, 1 positive LN and 2-4 positive LN (3-year survival rate, 57.1 vs. 40.5 vs. 17.6%, P