Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report
Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report
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DOI：
10.1007/s00167-010-1337-4
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发表时间：
2011-04-01
影响因子：
3.8
通讯作者：
Verdonk, P. C. M.
中科院分区：
文献类型：
--
作者：
Dhollander, A. A. M.;De Neve, F.;Verdonk, P. C. M.
本试验旨在描述自体基质诱导软骨形成（AMIC）结合富血小板血浆凝胶（AMIC+）技术治疗膝关节髌骨软骨缺损的技术细节和初步结果。AMIC+技术用于治疗膝关节（骨）软骨髌骨病变。广泛描述了手术技术。在2年内对5例患者进行了临床前瞻性评价。根据原始MOCART（Magnetic Resonance Observation of Carbonate Repair Tissue）和改良MOCART评分系统对MRI数据进行分析，随访24个月后临床改善明显。两种MOCART评分系统均显示在1年和2年随访期间修复组织无显著恶化或改善。然而，所有病例均显示软骨板下和骨改变。术后随访2年，5例患者中有3例出现病变内骨赘形成，AMIC+治疗症状性髌骨软骨缺损是可行的，所有患者的临床症状均得到改善。AMIC plus技术的良好临床结局未得到MRI结果的证实。
This pilot study was designed to describe the technical details and to present the preliminary outcome of autologous matrix-induced chondrogenesis (AMIC) combined with platelet-rich plasma gel, the so called AMIC plus technique, for the treatment of patellar cartilage defects in the knee.The AMIC plus technique was used for the treatment of (osteo) chondral patellar lesions in the knee. The surgical technique is extensively described. Five patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) and modified MOCART scoring system.A clinical improvement became apparent after 24 months of follow-up. Both MOCART scoring systems revealed no significant deterioration or improvement of the repair tissue between one and 2 years of follow-up. However, all cases showed subchondral lamina and bone changes. The formation of intralesional osteophytes was observed in 3 of the 5 patients during the 2 years of follow-up.AMIC plus is feasible for the treatment of symptomatic patellar cartilage defects and resulted in a clinical improvement in all patients. The favourable clinical outcome of the AMIC plus technique was not confirmed by the MRI findings.IV.