Cancer stem cells: a novel paradigm for cancer prevention and treatment.
Cancer stem cells: a novel paradigm for cancer prevention and treatment.
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DOI：
10.2174/138955710791330954
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Anant S
中科院分区：
文献类型：
--
作者：
Subramaniam D;Ramalingam S;Houchen CW;Anant S
癌症是美国仅次于心脏病的第二大死亡原因，缺乏良好或有效的治疗范例。尽管出现了新的靶向药物，并使用了各种治疗组合，但对晚期癌症患者来说，可用的治疗方案都不是根治的。越来越多的证据支持这样的观点，即人类癌症可以被视为一种干细胞疾病。恶性肿瘤被认为起源于一小部分癌细胞，这些癌细胞具有自我更新和多能性，并能够启动和维持肿瘤的生长。癌症起始细胞或癌症干细胞最初在血液系统恶性肿瘤中被发现，但现在在几种实体肿瘤中被识别。干细胞驱动的肿瘤发生假说提出了一个问题，即目前的治疗方法是否能够有效地靶向这些缓慢循环的肿瘤细胞。目前的治疗方法大多需要快速分裂细胞。癌症干细胞的最新特征应该导致识别关键的信号通路，这些信号通路可能使癌症干细胞容易受到针对药物分泌能力、抗凋亡机制和诱导分化的治疗干预。膳食植物化学物质具有抗癌特性，是预防和治疗多种癌症的一种有前途的方法。
Cancer is the second leading cause for mortality in US only after heart disease and lacks a good or effective therapeutic paradigm. Despite the emergence of new, targeted agents and the use of various therapeutic combinations, none of the treatment options available is curative in patients with advanced cancer. A growing body of evidence is supporting the idea that human cancers can be considered as a stem cell disease. Malignancies are believed to originate from a fraction of cancer cells that show self renewal and pluripotency and are capable of initiating and sustaining tumor growth. The cancer-initiating cells or cancer stem cells were originally identified in hematological malignancies but is now being recognized in several solid tumors. The hypothesis of stem cell-driven tumorigenesis raises questions as to whether the current treatments, most of which require rapidly dividing cells are able to efficiently target these slow cycling tumorigenic cells. Recent characterization of cancer stem cells should lead to the identification of key signaling pathways that may make cancer stem cells vulnerable to therapeutic interventions that target drug-effluxing capabilities, anti-apoptotic mechanisms, and induction of differentiation. Dietary phytochemicals possess anti-cancer properties and represent a promising approach for the prevention and treatment of many cancers.
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