Translational benchmark risk analysis.

Translational benchmark risk analysis.
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DOI:
10.1080/13669870903551662
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发表时间:
2010-07
影响因子:
5.1
通讯作者:
Piegorsch WW
Piegorsch WW
中科院分区:
管理学4区
文献类型:
--
作者:
Piegorsch WW

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转化发展——即将成熟的方法从一个应用领域转化到另一个不断发展的领域——讨论了定量风险评估中基准剂量的使用。插图展示了生物学和毒理学中基准范式的传统应用,以及与传统毒理学原型不同的风险终点。可以看出,基准方法可以适用于各种风险管理环境。这表明这一重要的风险分析工具有着光明的未来。该方法扩展到更广泛的应用领域,为加强环境、生物医学、工业和社会经济风险评估提供了重要机会。
Translational development – in the sense of translating a mature methodology from one area of application to another, evolving area – is discussed for the use of benchmark doses in quantitative risk assessment. Illustrations are presented with traditional applications of the benchmark paradigm in biology and toxicology, and also with risk endpoints that differ from traditional toxicological archetypes. It is seen that the benchmark approach can apply to a diverse spectrum of risk management settings. This suggests a promising future for this important risk-analytic tool. Extensions of the method to a wider variety of applications represent a significant opportunity for enhancing environmental, biomedical, industrial, and socio-economic risk assessments.
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