Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis.
Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis.
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DOI：
10.1038/srep09599
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发表时间：
2015-04-23
影响因子：
4.6
通讯作者：
Qu Y
中科院分区：
文献类型：
--
作者：
Chen F;Li Q;Yu Y;Yang W;Shi F;Qu Y
进行剂量反应荟萃分析来评估维生素 C、D、E 与膀胱癌风险的关联。 PubMed 和 Embase 中确定了相关研究。使用随机效应模型。饮食加补充剂中维生素 D 每增加 100 IU/天，膀胱癌的相对风险（95% 置信区间）为 0.99 (0.95–1.03)；循环维生素 D 每增加 10 nmol/L，膀胱癌相对风险为 0.95 (0.90–1.00)。饮食加补充剂中维生素 E 每增加 10 mg/天，膀胱癌的相对风险为 0.96 (0.90–1.02)。饮食中的效果为 0.83 (0.72–0.95)，补充剂中的效果为 0.88 (0.67–1.15)，循环 α-生育酚每增加 1 mg/dL，效果为 0.84 (0.76–0.94)；循环 γ-生育酚每增加 0.1 mg/dL，效果为 1.22 (1.00–1.49)。观察到的维生素 D 和维生素 E 的相关性在吸烟者中显着，但在非吸烟者中则不显着。剂量反应分析中未发现维生素 C 与膀胱癌风险之间存在显着关联。根据剂量反应分析，膀胱癌的风险可能与维生素 D 和 E（尤其是 α-生育酚）呈负相关，但与 γ-生育酚呈正相关。
A dose-response meta-analysis was conducted to assess the association of vitamin C, D, E with risk of bladder cancer. Pertinent studies were identified in PubMed and Embase. The random-effect model was used. The relative risk (95% confidence interval) of bladder cancer was 0.99 (0.95–1.03) for every 100 IU/day increment in vitamin D from diet plus supplement and 0.95 (0.90–1.00) for every 10 nmol/L increment in circulating vitamin D. The effect for every 10 mg/day increment was 0.96 (0.90–1.02) for vitamin E from diet plus supplement, 0.83 (0.72–0.95) from diet and 0.88 (0.67–1.15) from supplement, and the effect was 0.84 (0.76–0.94) for every 1 mg/dL increment in circulating α-Tocopherol and 1.22 (1.00–1.49) for every 0.1 mg/dL increment in circulating γ-Tocopherol. The observed association for vitamin D and vitamin E was significant among smokers but not among non-smokers. No significant association was found between vitamin C and risk of bladder cancer in the dose-response analysis. Based on the dose-response analysis, the risk of bladder cancer might be inversely associated with vitamin D and E (especially α-Tocopherol), but positively associated with γ-Tocopherol.