Tilt responses of neurons in the caudal descending nucleus of the decerebrate cat: influence of the caudal cerebellar vermis and of neck receptors.
Tilt responses of neurons in the caudal descending nucleus of the decerebrate cat: influence of the caudal cerebellar vermis and of neck receptors.
复制标题
去大脑猫尾部降核神经元的倾斜反应：尾部小脑蚓部和颈部受体的影响。
DOI：
10.1152/jn.1996.75.3.1242
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Thomson,DB
中科院分区：
文献类型：
--
作者：
Wilson,VJ;Ikegami,H;Schor,RH;Thomson,DB
1.在去脑猫与完整的小脑，我们研究了前庭核尾侧区的神经元的反应，自然前庭刺激在垂直平面和颈部旋转。大多数神经元的活动记录在下降核的尾侧半。2.我们的实验的一个目标是比较的动态和空间特性的反应，正弦前庭刺激与那些在以前的实验中，其中尾小脑蚓部，包括结节和悬雍垂，被删除。小脑的这一部分接受前庭输入，并投射到前庭核的尾侧区域，这表明它可以影响对迷路刺激的反应。3.在我们之前的实验中，大多数神经元可以被归类为从耳石或一个垂直半规管接收主要输入。当平均增益和相位和响应矢量方向进行比较，有没有明显的差异，在部分decerebellate准备和小脑完整的神经元的行为，表明在去大脑猫的结节和悬雍垂有很少或没有影响的处理垂直前庭输入在这个区域的前庭核。4. 74个神经元中只有23个（31%）对颈部旋转有反应。这与Deiters核和头侧降核中对这种刺激作出反应的更大部分形成对比。我们还记录了前庭核附近的神经元，主要是在外侧楔束核。所有患者（9/9）均对颈部旋转有反应。5.颈部旋转的反应也不同，在他们的动力学从那些发现更rostrally在前庭核。更多的吻侧神经元的动力学类似于颈肌梭，外侧楔叶神经元也是如此。另一方面，尾侧前庭神经元的动力学具有更陡的增益斜率和更高级的相位，比头侧前庭核中的神经元的增益斜率和更高级的相位。这表明在这些反应的产生中可能涉及额外的受体。6.在更吻侧的前庭核中，对前庭和颈部旋转的反应通常是对抗性的，因此头部旋转导致很少或没有反应。在前庭核的尾侧区域，情况并非如此，其中不到一半的神经元显示出对抗行为。需要进一步的实验，把颈部投射到前庭尾侧核的功能背景。
1. In decerebrate cats with intact cerebellums, we studied the responses of neurons in the caudal areas of the vestibular nuclei to natural vestibular stimulation in vertical planes and to neck rotation. The activity of most neurons was recorded in the caudal half of the descending nucleus. 2. One goal of our experiments was to compare the dynamic and spatial properties of responses to sinusoidal vestibular stimulation with those seen in previous experiments in which the caudal cerebellar vermis, including the nodulus and uvula, was removed. This part of the cerebellum receives vestibular input and projects to the caudal areas of the vestibular nuclei, suggesting that it could influence responses to stimulation of the labyrinth. 3. As in our previous experiments, most neurons could be classified as receiving predominant input either from the otoliths or from one vertical semicircular canal. When mean gain and phase and response vector orientations were compared, there were no obvious differences between the behavior of neurons in the partially decerebellate preparation and the one with the cerebellum intact, demonstrating that in the decerebrate cat the nodulus and uvula have little or no influence on the processing of vertical vestibular input in this region of the vestibular nuclei. 4. Only 23 of 74 (31%) of neurons tested responded to neck rotation. This contrasts with the much larger fractions that respond to this stimulus in Deiters' nucleus and in the rostral descending nucleus. We also recorded from neurons near the vestibular nuclei, mainly in the external cuneate nucleus. All of them (9 of 9) responded to neck rotation. 5. Responses to neck rotation also differed in their dynamics from those found more rostrally in the vestibular nuclei. Dynamics of more rostral neurons resemble those of neck muscle spindles, as do those of external cuneate neurons. The dynamics of caudal vestibular neurons, on the other hand, have a steeper gain slope and more advanced phases than do those of neurons in the more rostral vestibular nuclei. This suggests the possibility of involvement of additional receptors in the production of these responses. 6. In the more rostral vestibular nuclei, responses to vestibular and neck rotation are most often antagonistic, so that head rotation results in little or no response. This is not the case in the caudal areas of the vestibular nuclei, where less than half the neurons tested displayed antagonistic behavior. Further experiments are required to put the neck projection to the caudal vestibular nuclei in a functional context.