Influence of a five-day vegetarian diet on urinary levels of antibiotics and phthalate metabolites: A pilot study with "Temple Stay" participants
Influence of a five-day vegetarian diet on urinary levels of antibiotics and phthalate metabolites: A pilot study with "Temple Stay" participants
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DOI：
10.1016/j.envres.2010.02.008
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发表时间：
2010-05-01
影响因子：
8.3
通讯作者：
Choi, Kyungho
中科院分区：
文献类型：
--
作者：
Ji, Kyunghee;Kho, Young Lim;Choi, Kyungho
饮食被认为是暴露于许多环境污染物的手段。本研究的目的是了解饮食变化对暴露于几种环境化学品（特别是抗生素和邻苯二甲酸盐）水平的影响。为此，我们研究了饮食的短期变化在多大程度上影响了成年人无意中接触这些化学品的水平。我们在韩国招募了为期五天的“寺庙住宿”计划的参与者（n=25），并在计划前后收集了尿液样本。我们还在参与前对参与者的饮食模式进行了问卷调查。在项目期间，参与者遵循佛教僧侣的日常生活，并保持素食。分析了三种抗生素及其主要代谢物、四种主要邻苯二甲酸酯代谢物和作为氧化应激生物标志物的丙二醛（MDA）的尿液水平。抗生素和邻苯二甲酸酯的检测频率和水平在项目期间明显下降。尿MDA水平显著低于参与计划前（0.16 vs 0.27 mg/g肌酐）。尽管目标化合物的暴露可能会受到其他行为模式的影响，但这些结果表明，即使饮食行为的短期变化也可能显着减少无意中接触抗生素和邻苯二甲酸酯，从而可能降低氧化应激水平。(C)2010年爱思唯尔公司All rights reserved.
Diet is purported to be means of exposure to many environmental contaminants. The purpose of this study is to understand the influence of dietary change on the levels of exposure to several environmental chemicals - in particular, antibiotics and phthalates. For this purpose, we examined the extent to which short-term changes in diet influenced the inadvertent exposure levels to these chemicals in an adult population. We recruited participants (n=25) of a five-day 'Temple Stay' program in Korea and collected urine samples before and after the program. We also conducted a questionnaire survey on participants' dietary patterns prior to their participation. During the program, participants followed the daily routines of Buddhist monks and maintained a vegetarian diet. Urinary levels of three antibiotics and their major metabolites, metabolites of four major phthalates, and malondialdehyde (MDA) as an oxidative stress biomarker were analyzed. The frequency and levels of detection for antibiotics and phthalates noticeably decreased during the program. Urinary MDA levels were significantly lower than before program participation (0.16 versus 0.27 mg/g creatinine). Although the exposure to target compounds might be influenced by other behavioral patterns, these results suggest that even short-term changes in dietary behavior may significantly decrease inadvertent exposure to antibiotics and phthalates and hence may reduce oxidative stress levels. (C) 2010 Elsevier Inc. All rights reserved.