Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose.
Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose.
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DOI：
10.1146/annurev-nutr-071812-161201
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发表时间：
2014
影响因子：
8.9
通讯作者：
De Jonghe BC
中科院分区：
文献类型：
--
作者：
Hayes MR;Mietlicki-Baase EG;Kanoski SE;De Jonghe BC
可以说，所有真核生物最基本的生理系统是那些控制能量平衡的系统。没有足够的能量，个体就无法生存和繁殖。因此，一个不断增长的认识是，哺乳动物生理学发展了一套冗余的神经内分泌信号，调节能量的摄入和消耗，保持足够的循环能量，主要是以葡萄糖的形式，以确保整个身体的能量需求得到满足。这种协调的控制需要胃肠道之间的相互作用，胃肠道感觉到进入的膳食，胰腺产生血糖反调节激素，大脑控制自主和行为过程，调节能量平衡。因此，本文综述了肠促胰岛素激素胰高血糖素样肽-1（GLP-1）和胃抑制多肽（GIP）以及胰腺激素胰淀素对能量平衡和血糖控制的生理、药理和病理生理作用。
Arguably the most fundamental physiological systems for all eukaryotic life are those governing energy balance. Without sufficient energy, an individual is unable to survive and reproduce. Thus, an ever-growing appreciation is that mammalian physiology developed a redundant set of neuroendocrine signals that regulate energy intake and expenditure, which maintains sufficient circulating energy, predominantly in the form of glucose, to ensure that energy needs are met throughout the body. This orchestrated control requires cross-talk between the gastrointestinal tract which senses the incoming meal, the pancreas which produces glycemic counterregulatory hormones, and the brain which controls autonomic and behavioral processes regulating energy balance. Therefore, this review highlights the physiological, pharmacological, and pathophysiological effects of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP), as well as the pancreatic hormone amylin, on energy balance and glycemic control.
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影响因子：
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作者：
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