Meta-analysis of an association of codon 72 polymorphisms of the p53 gene with increased endometrial cancer risk
Meta-analysis of an association of codon 72 polymorphisms of the p53 gene with increased endometrial cancer risk
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p53 基因密码子 72 多态性与子宫内膜癌风险增加关联的荟萃分析
DOI：
10.4238/2011.october.31.11
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发表时间：
2011-01-01
影响因子：
0.4
通讯作者：
Zhang, S. L.
中科院分区：
文献类型：
--
作者：
Gu, Y.;Zhou, X.;Zhang, S. L.
p53基因的多态性与子宫内膜癌的易感性有关。然而，是否存在特定的关联仍存在争议。我们通过荟萃分析研究了p53密码子72多态性与子宫内膜癌风险之间的可能关联。从Pubmed、Embase和CBM数据库（截至2011年1月）中选择了涉及该相关性的出版物。数据由两位独立评论员从研究中提取。采用RevMan 5.0.25和STATA 9.2软件进行Meta分析。计算比值比（OR）和95%置信区间（CI）。然后检索了10项病例对照研究，共有917名子宫内膜癌患者和1680名健康对照。Meta分析结果显示，p53密码子72多态性的Pro等位基因和Pro携带者（Arg/Pro + Pro/Pro）与子宫内膜癌的风险显著相关（OR = 1.25，95%CI = 1.10-1.41，P = 0.0005; OR = 1.34，95%CI = 1.12-1.59，P = 0.001）。在亚组分析中，根据种族，研究被分为亚洲和高加索人群; Pro等位基因和Pro携带者p53基因第72位密码子（Arg/Pro + Pro/Pro）多态性与亚洲人群子宫内膜癌的风险显著相关（OR = 1.41，95% CI = 1.19-1.66，P < 0.0001; OR = 1.66，95% CI = 1.30-2.13，P < 0.0001），但在白种人中无显著性差异（均P > 0.05）。提示p53基因第72密码子Pro等位基因（Arg/Pro + Pro/Pro）是子宫内膜癌的潜在危险因素。
Polymorphisms of the p53 gene have been associated with susceptibility to endometrial cancer. However, whether there is a specific association is still controversial. We investigated a possible association between p53 codon 72 polymorphism and endometrial cancer risk by conducting a meta-analysis. Publications addressing this association were selected from the Pubmed, Embase and CBM databases (up to January 2011). Data were extracted from the studies by two independent reviewers. The meta-analysis was performed using RevMan 5.0.25 and STATA 9.2 softwares. The odds ratio (OR) with 95% confidence intervals (CI) was calculated. Then, 10 case-control studies were retrieved, with a total of 917 endometrial cancer patients and 1680 healthy controls. Meta-analysis results showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism were significantly related with endometrial cancer risk (OR = 1.25, 95% CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95% CI = 1.12-1.59, P = 0.001, respectively). In the subgroup analysis, based on ethnicity, studies were divided into Asian and Caucasian populations; the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism were significantly related with endometrial cancer risk in Asian populations (OR = 1.41, 95% CI = 1.19-1.66, P < 0.0001; OR = 1.66, 95% CI = 1.30-2.13, P < 0.0001, respectively), but not in Caucasian populations (both P > 0.05). We concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism is a potential risk factor for endometrial cancer.