Correlation between MMP-2 and NF- κ B expression of intracranial aneurysm
Correlation between MMP-2 and NF- κ B expression of intracranial aneurysm
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DOI：
10.1016/s1995-7645(13)60098-x
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发表时间：
2013-07-01
影响因子：
3.1
通讯作者：
Wang, Ning
中科院分区：
文献类型：
--
作者：
Cheng, Wei-Tao;Wang, Ning
目的：研究基质金属蛋白酶-2(MMP2)和核因子-kappaB(NFkappaB)在颅内动脉瘤壁中的表达及其相关性，探讨其在动脉瘤发生、生长和破裂机制中的作用。方法：采用RT-PCR方法检测30例颅内动脉瘤组织和10例正常颅内动脉组织中基质金属蛋白酶-2和核因子-kappaB的表达，免疫组织化学方法检测基质金属蛋白酶-2和核因子-kappaB蛋白的表达。结果：在动脉瘤组织和正常组织中，基质金属蛋白酶-2和核因子-kappaB的半定量分析差异有统计学意义(P
Objective: To investigate the correlation between expressions of MMP-2 and NF- kappa B in the intracranial aneurysm wall, and explore their role in the mechanism of the occurrence, growth and rupture of intracranial aneurysms. Methods: RT-PCR was used to detect the expression of MMP-2 and NF- kappa B mRNA of 30 cases of intracranial aneurysm tissue and 10 cases of normal intracranial arterial tissue; Immunohistochemical method was used to detect the expression of MMP-2 and NF- kappa B protein. Results: The semi-quantitative analysis of MMP-2 and NF- kappa B in aneurysms tissues and normal tissues were statistically significant different from each other (P