Changes in the concentration of endothelin-1 during development of hypertensive rats.
Changes in the concentration of endothelin-1 during development of hypertensive rats.
复制标题
高血压大鼠发育过程中内皮素-1浓度的变化。
作者：
Ravi Iyer;Govind Singh;Sam Rebello;Sujoy Roy;Rama Bhat;Dharmapuri Vidyasagar;Anil Gulati
用放射免疫法测定了1、4、6、8周龄自发性高血压(SHR)大鼠和血压正常的Wistar-京都(WKY)大鼠脑区、心脏和胸主动脉组织中内皮素-1(ET-1)的浓度。出生1周的WKY和SHR大鼠脑区的ET-1样免疫反应比老年(6周和8周)大鼠低。SHR和WKY大鼠中枢神经系统内ET-1水平均随增龄而逐渐升高。然而，8周龄SHR大鼠脑区ET-1浓度低于WKY大鼠。1周龄SHR(224+/-43pg/g组织)大鼠胸主动脉ET-1浓度低于WKY(452+/-11pg/g组织)大鼠。而SHR大鼠随年龄增长，ET-1水平逐渐升高。到8周龄时，SHR(623+/-33pg/g组织)大鼠的ET-1水平高于WKY(439+/-62pg/g组织)大鼠。在心脏方面，4周龄WKY和SHR大鼠的ET-1水平相似，但8周龄SHR大鼠的ET-1水平(364+/-33pg/g组织)高于WKY大鼠(260+/-31pg/g组织)。与WKY大鼠相比，8周龄的SHR大鼠的中枢神经系统ET-1水平较低，胸主动脉和心脏的ET-1水平较高。
The concentration of endothelin-1 (ET-1) in the brain regions, heart, and throacic aorta of 1-, 4-, 6- and 8-week-old spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats was determined using radioimmunoassay. ET-1-like immunoreactivity in the brain regions of 1-week-old WKY and SHR rats was lower compared to older (6 and 8 weeks) rats. ET-1 levels in the central nervous system gradually increased with age in both SHR and WKY rats. However, the concentration of ET-1 in 8-week-old rats was lower in the brain regions of SHR compared to WKY rats. The concentration of ET-1 in the thoracic aorta of SHR (224 +/- 43 pg/g tissue) rats was lower than that of WKY (452 +/- 11 pg/g tissue) rats at 1 week of age. However, ET-1 levels gradually increased with age in SHR rats. By 8 weeks of age, levels of ET-1 in SHR (623 +/- 33 pg/g tissue) rats were higher compared to WKY (439 +/- 62 pg/g tissue) rats. In the heart, ET-1 levels were similar in WKY and SHR rats at 4 weeks of age, but at 8 weeks of age ET-1 levels were higher in SHR rats (364 +/- 33 pg/g tissue) compared to WKY rats (260 +/- 31 pg/g tissue). It appears that at 8 weeks of age when hypertension is fully expressed in rats, ET-1 levels are lower in the central nervous system and are higher in the thoracic aorta and heart of SHR compared to WKY rats.