Multicentric study on malignant pleural mesothelioma and non-occupational exposure to asbestos
Multicentric study on malignant pleural mesothelioma and non-occupational exposure to asbestos
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恶性胸膜间皮瘤与非职业石棉接触的多中心研究
DOI：
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发表时间：
2000
影响因子：
8.8
通讯作者：
Benedetto Terracini
中科院分区：
文献类型：
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作者：
C. Magnani;Antonio Agudo;González Ca;A. Andrion;A. Calleja;Elisabetta Chellini;Paola Dalmasso;Antonio Escolar;S. Hernández;C. Ivaldi;D. Mirabelli;J. Ramírez;D. Turuguet;M. Usel;Benedetto Terracini
没有足够的证据表明非职业性接触石棉会导致胸膜间皮瘤。在来自意大利、西班牙和瑞士的六个地区进行了一项以人群为基础的病例对照研究。收集了215例新的组织学确诊病例和448例对照病例的信息。一个工业卫生专家小组分别评估了职业、家庭和环境来源的石棉暴露。家庭和环境暴露的分类是基于完整的居住历史、家中石棉的存在和使用、周围地区的石棉工业活动以及与住所的距离。在53例病例和232例对照中，没有证据表明职业暴露于石棉，中度或高度的家庭暴露概率与年龄和性别调整后的风险增加相关：比值比（OR）4.81，95%置信区间（CI）1.8-13.1。这对应于三种情况：清洁石棉污染的衣服、处理石棉材料和存在易受损害的石棉材料。高环境暴露概率（居住在石棉矿、石棉水泥厂、石棉纺织品、造船厂或制动器厂2000 m范围内）的估计OR为11.5（95% CI 3.5-38.2）。居住在距离石棉工业2000米至5000米之间或距离使用石棉的工业500米以内的地区也可能增加风险。两种暴露源的强度均出现剂量-反应模式。这表明，低剂量暴露于石棉在家里或在一般环境中进行恶性胸膜间皮瘤的可测量的风险。2000癌症研究运动
Insufficient evidence exists on the risk of pleural mesothelioma from non-occupational exposure to asbestos. A population-based case–control study was carried out in six areas from Italy, Spain and Switzerland. Information was collected for 215 new histologically confirmed cases and 448 controls. A panel of industrial hygienists assessed asbestos exposure separately for occupational, domestic and environmental sources. Classification of domestic and environmental exposure was based on a complete residential history, presence and use of asbestos at home, asbestos industrial activities in the surrounding area, and their distance from the dwelling. In 53 cases and 232 controls without evidence of occupational exposure to asbestos, moderate or high probability of domestic exposure was associated with an increased risk adjusted by age and sex: odds ratio (OR) 4.81, 95% confidence interval (CI) 1.8–13.1. This corresponds to three situations: cleaning asbestos-contaminated clothes, handling asbestos material and presence of asbestos material susceptible to damage. The estimated OR for high probability of environmental exposure (living within 2000 m of asbestos mines, asbestos cement plants, asbestos textiles, shipyards, or brakes factories) was 11.5 (95% CI 3.5–38.2). Living between 2000 and 5000 m from asbestos industries or within 500 m of industries using asbestos could also be associated with an increased risk. A dose–response pattern appeared with intensity of both sources of exposure. It is suggested that low-dose exposure to asbestos at home or in the general environment carries a measurable risk of malignant pleural mesothelioma. © 2000 Cancer Research Campaign