Dietary calcium and lead interact to modify maternal blood pressure, erythropoiesis, and fetal and neonatal growth in rats during pregnancy and lactation.
Dietary calcium and lead interact to modify maternal blood pressure, erythropoiesis, and fetal and neonatal growth in rats during pregnancy and lactation.
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膳食钙和铅相互作用，可改变妊娠和哺乳期间大鼠的母体血压、红细胞生成以及胎儿和新生儿的生长。
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Sheldon B. Gertner
中科院分区：
文献类型：
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作者：
J. Bogden;F. Kemp;Shenggao Han;M. Murphy;Mitchell Fraiman;Donald Czerniach;Carina J. Flynn;Michael L. Banua;Anthony Scimone;Lorainne Castrovilly;Sheldon B. Gertner
研究了孕期和哺乳期膳食钙和铅暴露对大鼠铅毒性、胎儿和新生儿生长、红细胞生成和血压的影响。将妊娠Sprague-Dawley大鼠（n = 43）随机分配至6个处理组之一，每组7-8只大鼠。一半的大鼠喂养饮食的低（0.1%），正常（0.5%）或高（2.5%）的碳酸钙钙和暴露于250毫克/升的铅在其饮用水的怀孕期间和1周的哺乳期。三个对照组喂食相同的饮食，没有铅暴露。在1日龄和1周龄时对幼仔进行研究。来自低钙饮食组的母体和胎儿血液和器官样本的铅浓度最高，而高钙饮食组的铅浓度最低。母鼠和幼鼠血红蛋白浓度、血细胞比容、体重和身长均因铅暴露和高钙饮食而降低。后者还降低了器官铁浓度，并防止铅诱导的游离红细胞原卟啉增加。在妊娠晚期，暴露于铅并喂食低钙饮食的大鼠的母体收缩压显著高于其他五个治疗组的大鼠。结果表明，膳食中的钙和铅暴露在大鼠中相互作用，影响母体血压，红细胞生成，胎儿和新生儿的生长在妊娠期和哺乳期。
We studied the effects of dietary calcium and lead exposure on lead toxicity, fetal and neonatal growth, erythropoiesis and blood pressure during pregnancy and lactation in rats. Pregnant Sprague-Dawley rats (n = 43) were randomly assigned to one of six treatment groups of 7-8 rats each. Half of the rats were fed diets of low (0.1%), normal (0.5%) or high (2.5%) calcium as calcium carbonate and exposed to 250 mg/L of lead in their drinking water for the duration of the pregnancy and for 1 wk of lactation. Three control groups were fed the same diets without lead exposure. Pups were studied at 1 d and 1 wk of age. Maternal and fetal blood and organ samples from the groups fed the low calcium diet had the highest lead concentrations, whereas the lowest lead concentrations were found in the groups fed the high calcium diet. Dam and pup hemoglobin concentrations, hematocrits, and body weights and lengths were reduced by lead exposure and by the high calcium diet. The latter also reduced organ iron concentrations and prevented lead-induced increases in free erythrocyte protoporphyrin. Dam systolic blood pressures during the third trimester of gestation were significantly higher in rats exposed to lead and fed the low calcium diet than in rats in the other five treatment groups. The results demonstrate that dietary calcium and lead exposure interact in rats to influence maternal blood pressure, erythropoiesis, and fetal and neonatal growth during pregnancy and lactation.