Apolipoprotein E genotype and plasma levels in coronary artery disease. A case-control study in the Italian population
Apolipoprotein E genotype and plasma levels in coronary artery disease. A case-control study in the Italian population
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DOI：
10.1016/s0009-9120(99)00011-9
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发表时间：
1999-04-01
影响因子：
2.8
通讯作者：
Scacchi, R
中科院分区：
文献类型：
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作者：
Corbo, RM;Vilardo, T;Scacchi, R
7目标：研究载脂蛋白B和载脂蛋白E多态性在意大利人群冠心病（CAD）易感性中的作用及其与血脂和载脂蛋白水平的关系。方法：对150例男性CAD患者和110例匹配对照者的APOB（APOB XbaI，EcoRI，Ins/Del）和APOE（APOE Cfol）多态性进行分析。结果：APOB基因多态性在冠心病组和对照组中的分布无显著性差异。患者中e*4携带者的数量显著高于对照组。E*4携带者在高血压患者中更常见，并且具有比非E *4携带者更高的收缩压（p = 0.007）。APOB XbaI多态性影响HDL-胆固醇的分布。患者的apoE水平显著降低（39.29 mg/L）（54.32 mg/dL），最低浓度与E4/E3和E4/E4基因型相关。定量数据与apoE具有抗动脉粥样硬化作用的假设一致，并表明apoE定量可能是定义心血管风险的有用参数，e*4等位基因似乎是意大利人群中CAD的一个危险因素，可能与低apoE水平相关。版权所有（C）1999加拿大临床化学家协会。
7Objectives: To investigate the role of the apolipoprotein B and apolipoprotein E polymorphisms in coronary artery disease (CAD) susceptibility in the Italian population and their relation to plasma lipid and apolipoprotein levels.Methods: APOB (APOB XbaI, EcoRI, Ins/Del), and APOE (APOE Cfol) polymorphisms were analyzed in 150 male CAD patients and 110 matched controls. In the same subjects plasma lipid, apoB, and apoE levels were measured.Results: No differences in the distribution of the APOB polymorphisms were observed between patients and controls. Among patients the number of e*4-carriers was significantly higher than in controls. e*4-carriers were more frequent among the hypertensive patients and had a higher systolic blood pressure (p = 0.007) than the non-e*4 carriers. The APOB XbaI polymorphism was found to influence the distribution of HDL-cholesterol. Patients showed significantly lower levels of apoE (39.29 mg/L) than controls (54.32 mg/dL) and the lowest concentrations were associated to the E4/E3 and E4/E4 genotypes.Conclusion: Quantitative data are consistent with the hypothesis that apoE has an anti-atherosclerotic role and suggest that the apoE quantitation could be a useful parameter for defining cardiovascular risk, e*4 allele appears to be a risk factor for CAD in the Italian population and could act by its association with low apoE levels. Copyright (C) 1999 The Canadian Society of Clinical Chemists.