Natriuretic peptides and genesis of asthma: An emerging paradigm?
Natriuretic peptides and genesis of asthma: An emerging paradigm?
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DOI：
10.1016/j.jaci.2004.05.028
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发表时间：
2004-09-01
影响因子：
14.2
通讯作者：
Gower, WR
中科院分区：
文献类型：
--
作者：
Mohapatra, SS;Lockey, RF;Gower, WR
暴露于过敏原和感染有助于早期免疫发展。然而，对细胞代谢、生理和内分泌因素在控制免疫发育和哮喘中的作用的了解有限。免疫细胞包括巨噬细胞、树突状细胞和T淋巴细胞，在胎儿和新生儿的淋巴器官中都表达心钠素(ANP)受体。心钠素因其心血管作用而备受关注，但其在肺的生理和免疫中的重要作用却被低估。研究表明，ANP在形成对环境抗原的早期免疫反应中也起着重要作用。C末端前激素利钠肽ANP(或NP99-126)具有支气管扩张特性，参与极化树突状细胞产生T(H)2反应。此外，另一种心钠素前体NP73-102的从头过表达提供了持续的支气管保护，并在肺上皮细胞中诱导了显著的抗炎活性。因此，利钠肽似乎在哮喘的发生和控制中起着关键作用，它们可能为调节过敏患者的过敏原诱导的免疫反应提供一个重要的靶点。
Exposure to allergens and infections contribute to early immune development. However, knowledge of the role of cellular metabolic, physiologic, and endocrinologic factors in controlling immune development and asthma is limited. Immune cells, including macrophages, dendritic cells, and T lymphocytes, express receptors for atrial natriuretic peptide (ANP) both in the fetal and neonatal lymphoid organs. ANP has garnered much attention for its cardiovascular effects, but its apparently significant role in the physiology and immunity of the lung has been underappreciated. Studies indicate that ANP also plays a significant role in shaping the early immune responses to environmental antigens. The C-terminal prohormone natriuretic peptide ANP (or NP99-126), which possesses bronchodilatory properties, is involved in polarizing dendritic cells to produce a T(H)2 response. Also, de novo overexpression of another pro-ANP peptide, NP73-102, provides persistent bronchoprotection and induces significant anti-inflammatory activities in the lung epithelial cells. Thus natriuretic peptides appear to play a pivotal role in the genesis and control of asthma, and they might provide an important target to modulate allergen-induced immune responses in allergic patients.