mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit.
mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit.
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发表时间：
1998
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通讯作者：
S. Roy;H. C. Liu;H. Loh
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作者：
S. Roy;H. C. Liu;H. Loh
使用μ-阿片受体敲除小鼠（MOR-KO）研究μ-阿片受体在胃肠转运中的作用。我们的研究结果明确表明，吗啡抑制胃肠道转运是一种μ阿片受体介导的功能。此外，我们表明，无论是δ或κ受体激动剂给予supraspinally或外周能够抑制胃肠道运输MOR-KO动物。有趣的是，观察到MOR-KO（-/-）中的基础GI运动性低于杂合（+/-）和野生型（+/+）动物。
The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a mu-opioid receptor mediated function. In addition, we show that neither delta nor kappa receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (+/-) and wild type (+/+) animals.