The olfactory bulb volume in patients with idiopathic Parkinson's disease
The olfactory bulb volume in patients with idiopathic Parkinson's disease
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DOI：
10.1111/ene.12709
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发表时间：
2015-07-01
影响因子：
5.1
通讯作者：
Witt, K.
中科院分区：
文献类型：
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作者：
Paschen, L.;Schmidt, N.;Witt, K.
背景和目的本研究旨在探讨特发性帕金森病（IPD）患者嗅球（OB）的神经病理学改变是否与嗅球体积的可检测变化相对应。此外，OB体积和残余嗅觉功能，临床疾病特征和年龄之间的关系investigated.MethodsFifty-two IPD患者进行了调查，并与31名健康的年龄匹配的对照。所有参与者均使用3 T磁共振成像MRI扫描仪进行扫描，包括通过OB在冠状切片中的T2 DRIVE序列。通过OB的手动分割测量OB体积。结果IPD组右侧嗅球体积为42.1mm（3）（SD 11.6），左侧嗅球体积为41.5mm（3）（SD +/- 11.7），与对照组无差异。此外，OB体积与疾病特征（如疾病持续时间或统一帕金森病评定量表运动评分）之间无显著相关性。同样，患者的残余嗅觉功能与他们的OB体积无关。与此相反，控制表明嗅觉功能和OB volume.ConclusionThe研究表明，高分辨率MRI并没有表现出可检测的体积损失的OB在PD患者之间的相关性。结论：使用3 T活体高分辨率MRI进行OB测量无助于识别IPD。
Background and purposeThis study addresses the question of whether the neuropathological findings on the olfactory bulb (OB) in idiopathic Parkinson's disease (IPD) correspond to a detectable change in volume of the OB. Additionally, the relationship between OB volume and residual olfactory function, clinical disease characteristics and age are investigated.MethodsFifty-two IPD patients were investigated and compared to 31 healthy age-matched controls. All participants were scanned using a 3 T magnetic resonance imaging MRI scanner including a T2 DRIVE sequence in coronal slices through the OB. The OB volumes were measured via manual segmentation of the OB. Olfactory testing was carried out using the Sniffin' Sticks test battery.ResultsThe OB volume in the IPD group was 42.1mm(3) (SD11.6) for the right and 41.5mm(3) (SD +/- 11.7) for the left OB and showed no difference from the controls. Additionally, there were no significant correlations between OB volume and disease characteristics such as disease duration or Unified Parkinson's Disease Rating Scale motor score. Likewise, patients' residual smell function did not correlate with their OB volume. In contrast, controls indicated a correlation between smell function and OB volume.ConclusionThe study shows that high resolution MRI does not show a detectable volume loss of the OB in PD patients. It is concluded that OB measurement using invivo high resolution MRI at 3 T is not helpful to identify IPD.