Effect of Cycling Thalamosubthalamic Stimulation on Tremor Habituation and Rebound in Parkinson Disease
Effect of Cycling Thalamosubthalamic Stimulation on Tremor Habituation and Rebound in Parkinson Disease
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DOI：
10.1016/j.wneu.2020.08.141
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发表时间：
2020-12-01
影响因子：
2
通讯作者：
Mikuni, Nobuhiro
中科院分区：
文献类型：
--
作者：
Enatsu, Rei;Kitagawa, Mayumi;Mikuni, Nobuhiro
背景：脑深部电刺激是治疗原发性震颤和帕金森病（PD）中严重震颤的有效方法。然而，进行性脑深部电刺激的有益效果的损失可能会发生由于几个factor.CASE描述：我们评估了不同的时间模式的循环刺激的影响，在后丘脑底区，丘脑底核，丘脑腹侧中间核3 PD患者的震颤抑制早期下降与严重的震颤反弹。某些时间循环模式（10秒开/1秒关或30秒开/5秒关，软启动关闭）可用于治疗震颤习惯和反弹，并显示长期震颤抑制。骑自行车刺激可以防止PD患者的震颤习惯与严重的震颤反弹。
BACKGROUND: Deep brain stimulation is an effective treatment for severe tremor in essential tremor and Parkinson disease (PD). However, progressive loss of the beneficial effects of deep brain stimulation may occur due to several factors.CASE DESCRIPTION: We assessed the effects of different temporal patterns of cycling stimulation in the posterior subthalamic area, subthalamic nucleus, and the ventral intermediate nucleus of the thalamus in 3 PD patients with early decline of tremor suppression associated with severe tremor rebound.CONCLUSIONS: Certain temporal patterns of cycling (10 seconds on/1 second off or 30 seconds on/5 seconds off, soft start off) were useful for treating tremor habituation and rebound and showed long-term tremor suppression. Cycling stimulation may prevent tremor habituation in PD patients with severe tremor rebound.