A cohort study of trends in the prevalence of pregestational diabetes in pregnancy recorded in UK general practice between 1995 and 2012.
A cohort study of trends in the prevalence of pregestational diabetes in pregnancy recorded in UK general practice between 1995 and 2012.
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DOI：
10.1136/bmjopen-2015-009494
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发表时间：
2016-01-25
期刊：
影响因子：
2.9
通讯作者：
Petersen I
中科院分区：
文献类型：
--
作者：
Coton SJ;Nazareth I;Petersen I
描述有和无妊娠糖尿病的孕妇的特征，并估计英国初级保健数据库中记录的孕妇妊娠糖尿病的患病率。本研究的数据来源是健康改善网络（THIN）初级保健数据库。16岁及16岁以上的孕妇中有糖尿病和无糖尿病的孕妇通过诊断性阅读代码和病历中的抗糖尿病药物处方进行识别。 数据进行了检查：年龄，体重指数（BMI），社会剥夺，吸烟，种族和贫血控制。根据1995年至2012年期间的糖尿病类型和日历年计算了妊娠前糖尿病的患病率。来自400434例妊娠的数据表明，患有孕前糖尿病的女性年龄较大（1型，2型和无糖尿病的中位数分别为29岁，32岁和29岁），BMI较高（1型，2型和无糖尿病的中位数分别为25.0，30.4和23.9 k/m2），并且与无糖尿病的孕妇相比，在全科诊所注册的时间更长。 1995年至2015年期间，妊娠期1型糖尿病的患病率从每1000例妊娠1.56例增加到4.09例。1995年至2008年期间，2型糖尿病从每1000例妊娠中的2.34例增加到5.09例，随后到2012年增加到每1000例妊娠中的10.62例。患有妊娠前糖尿病的孕妇年龄较大，BMI较高，登记时间长于未患糖尿病的妇女。妊娠期1型和2型糖尿病的患病率增加。2型糖尿病的患病率上升更快，2008年后显著增加。
To describe the characteristics of pregnant women with and without pregestational diabetes and to estimate the prevalence of pregestational diabetes in pregnant women recorded in a UK primary care database. The data source for this study is The Health Improvement Network (THIN) primary care database. Pregnant women with and without diabetes aged 16 years and over were identified using diagnostic Read codes and prescriptions for antidiabetics from medical records. Data were examined on: age, body mass index (BMI), social deprivation, smoking, ethnicity and glycaemic control. The prevalence of pregestational diabetes was calculated by diabetes type and calendar year between 1995 and 2012. Data from 400 434 pregnancies suggests that women with pregestational diabetes were: older (median 29, 32 vs 29 years for type 1, type 2 and without diabetes, respectively), had higher BMI (median 25.0, 30.4 vs 23.9 k/m2 for type 1, type 2 and without diabetes, respectively) and were registered with a general practice for longer than pregnant women without diabetes. The prevalence of type 1 diabetes in pregnancy increased from 1.56 to 4.09 per 1000 pregnancies between 1995 and 2015. For type 2 diabetes the increase was from 2.34 to 5.09 per 1000 pregnancies between 1995 and 2008 followed by a more rapid increase to 10.62 per 1000 pregnancies by 2012. Pregnant women with pregestational diabetes were older, had higher BMI and were registered for longer than women without diabetes. The prevalence of type 1 and type 2 diabetes increased in pregnancy. The prevalence of type 2 diabetes rose more rapidly with a marked increase after 2008.