Structural deficits in salience network regions are associated with increased impulsivity and compulsivity in alcohol dependence
Structural deficits in salience network regions are associated with increased impulsivity and compulsivity in alcohol dependence
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DOI：
10.1016/j.drugalcdep.2017.06.014
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发表时间：
2017-10-01
影响因子：
4.2
通讯作者：
Momenan, Reza
中科院分区：
文献类型：
--
作者：
Grodin, Erica N.;Cortes, Carlos R.;Momenan, Reza
背景：越来越多的临床前和临床证据表明，脑岛前部与冲动和酒精相关的强迫行为有关。前岛在功能上与前扣带皮层相连，共同构成突出网络的主要节点，该网络用于向突出事件发出信号，包括负面后果。临床研究发现，酒精依赖个体的前岛和前扣带皮层存在结构和功能上的改变。目前还没有研究调查突出网络区域的形态测量异常与酒精依赖个体的高水平冲动和强迫表型之间的关系。方法：在当前的研究中，我们比较了酒精依赖个体（n = 60）和健康对照组（n - 49）的自我报告冲动、决策冲动、自我报告强迫和结构神经成像测量。在结构磁共振图像前，我们计算了6个感兴趣区域的体积和皮质厚度：左右前岛，后岛和前扣带。结果：我们发现酒精依赖个体的前岛和前扣带体积较小，以及前岛皮层较薄。各组间脑岛后叶形态差异无统计学意义。前脑岛和前扣带结构测量与自我报告冲动性、决策冲动性和强迫性测量呈负相关。结论：我们的研究结果表明，酒精成瘾的成瘾内表型与显著网络形态学有关。这些关系表明，突出网络枢纽代表了包括酒精成瘾在内的冲动控制障碍的潜在治疗目标。
Background: Convergent preclinical and clinical evidence has linked the anterior insula to impulsivity and alcohol-associated compulsivity. The anterior insula is functionally connected to the anterior cingulate cortex, together comprising the major nodes of the salience network, which serves to signal salient events, including negative consequences. Clinical studies have found structural and functional alterations in the anterior insula and anterior cingulate cortices of alcohol dependent individuals. No studies have yet investigated the association between morphometric abnormalities in salience network regions and the phenotype of high levels of impulsivity and compulsivity seen in alcohol dependent individuals.Methods: In the current study, we compared self-report impulsivity, decisional impulsivity, self-report compulsivity, and structural neuroimaging measures in a sample of alcohol dependent individuals (n = 60) and a comparison group of healthy controls (n - 49). Front the structural magnetic resonance images, we calculated volume and cortical thickness for 6 regions of interest: left and right anterior insula, posterior insula, and anterior cingulate.Results: We found that alcohol dependent individuals had smaller anterior insula and anterior cingulate volumes, as well as thinner anterior insula cortices. There were no group differences in posterior insula morphometry. Anterior insula and anterior cingulate structural measures were negatively associated with self-report impulsivity, decisional impulsivity, and compulsivity measures.Conclusions: Our results suggest that addiction endophenotypes are associated with salience network morphometry in alcohol addiction. These relationships indicate that salience network hubs represent potential treatment targets for impulse control disorders, including alcohol addiction.