Hypoglycemic and antioxidant effects of leaf essential oil of Pelargonium graveolens L'Hér. in alloxan induced diabetic rats.
Hypoglycemic and antioxidant effects of leaf essential oil of Pelargonium graveolens L'Hér. in alloxan induced diabetic rats.
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DOI：
10.1186/1476-511x-11-81
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发表时间：
2012-06-26
影响因子：
4.5
通讯作者：
Sayadi S
中科院分区：
文献类型：
--
作者：
Boukhris M;Bouaziz M;Feki I;Jemai H;El Feki A;Sayadi S
有玫瑰香味的天竺葵（Pelargonium graveolens L’h<s:1> .）在突尼斯传统民间医学中用于治疗高血糖，被广泛认为是具有最高抗氧化活性的草药之一。本文对石竹叶精油的降血糖和抗氧化活性进行了研究。大鼠按75 mg/kg和150 mg/kg体重（b.w.）剂量每日和口服石竹挥发油30 d。测定了石竹挥发油的化学成分、体重、血清葡萄糖、肝糖原、硫代巴比妥酸反应物质（TBARS）、肝脏、肾脏和血清抗氧化系统的成分。将玫瑰天竺葵与已知降糖药格列本脲（600 μg/kg b.w）的降糖作用进行比较。服用了两剂天竺葵精油后。与具有抗糖尿病活性的格列本脲（600 μg/kg b.w）联合使用4周后，血清葡萄糖显著降低，抗氧化功能恢复。150 mg/kg b.w.剂量下的降糖效果显著优于格列苯脲（p< 0.05）。正是通过对糖尿病大鼠肝脏和肾脏组织的组织学观察，证实了天竺葵精油的这些有益作用。提示给药石竹挥发油可能有助于预防氧化应激相关的糖尿病并发症。因此，我们的研究结果表明，玫瑰香味的天竺葵可以作为一种安全的替代降糖药物用于糖尿病患者。
Rose-scented geranium (Pelargonium graveolens L’Hér.), which is used in traditional Tunisian folk medicine for the treatment of hyperglycaemia, is widely known as one of the medicinal herbs with the highest antioxidant activity. The present paper is conducted to test the hypoglycemic and antioxidative activities of the leaf essential oil of P. graveolens. The essential oil P. graveolens was administered daily and orally to the rats at two doses of 75 mg/kg and 150 mg/kg body weight (b.w.) for 30 days. The chemical composition of P. graveolens essential oil, body weight, serum glucose, hepatic glycogen, thiobarbituric acid-reactive substances (TBARS), the components of hepatic, and renal and serum antioxidant systems were evaluated. The hypoglycemic effect of rose-scented geranium was compared to that of the known anti-diabetic drug glibenclamide (600 μg/kg b.w.). After the administration of two doses of essential oil of Pelargonium graveolens L’Hér. together with glibenclamide which is known by its antidiabetic activities and used as reference (600 μg/kg b.w.), for four weeks, the serum glucose significantly decreased and antioxidant perturbations were restored. The hypoglycemic effect of P. graveolens at the dose of 150 mg/kg b.w. was significantly (p< 0.05) more effective than that of glibenclamide. It is through the histological findings in hepatic and renal tissues of diabetic rats that these beneficial effects of geranium oils were confirmed. It suggests that administration of essential oil of P. graveolens may be helpful in the prevention of diabetic complications associated with oxidative stress. Our results, therefore, suggest that the rose-scented geranium could be used as a safe alternative antihyperglycemic drug for diabetic patients.