A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China.
A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China.
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DOI：
10.1080/21501203.2021.1994479
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Huang G
中科院分区：
文献类型：
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作者：
Bing J;Wang S;Xu H;Fan S;Du H;Nobile CJ;Huang G
最近出现的真菌病原体耳念珠菌通常对一种或多种抗真菌药物具有耐药性。迄今为止，已在六大洲至少40个国家发现了感染病例。在此，我们报告一例在中国南方城市厦门的患者耳念珠菌感染。我们还回顾了目前在中国报道的金黄色葡萄球菌感染病例，并比较了从中国分离的金黄色葡萄球菌菌株的遗传和生物学特征。我们的系统发育分析表明，在中国至少有两个金耳金银花遗传支系（南非支系和南亚支系）显示出相反的交配型位点（一个是MTLa，另一个是MTLα）。我们还发现，在研究的临床分离株中有几个明显的特征，包括毒力因子的表达、抗真菌敏感性和细胞形态，这些特征可能与分离株的交配类型有关。例如，在环境温度下，耳C. auris MTLa分离株通常分泌较高水平的分泌天冬氨酸蛋白酶（Saps）。综上所述，本研究表明来自中国的金黄色葡萄球菌临床分离株在生物学和遗传特征上都表现出多样性。
The recently emerged fungal pathogen Candida auris often displays resistance to one or more antifungal drugs. Its infections have been identified in at least 40 countries on six continents to date. Here we report a case of C. auris candidemia in a patient in Xiamen, a city in south China. We also review currently reported cases of C. auris infection in China and compare the genetic and biological features of C. auris strains isolated from this country. Our phylogenetic analysis indicates that there are at least two C. auris genetic clades present in China (the South African clade and the south Asian clade) that display opposite mating type loci (one is MTLa and the other is MTLα). We also found that there are several distinct features among the clinical isolates studied, including the expression of virulence factors, antifungal susceptibilities, and cellular morphologies, and that these features could be associated with the mating-type of the isolate. For example, C. auris MTLa isolates generally secreted higher levels of secreted aspartyl proteases (Saps) at ambient environmental temperatures. Taken together, this study demonstrates that C. auris clinical isolates from China exhibit diversity in both biological and genetic features.