Active interfacial shear microrheology of aging protein films.
Active interfacial shear microrheology of aging protein films.
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DOI：
10.1103/physrevlett.104.016001
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发表时间：
2010-01-08
影响因子：
8.6
通讯作者：
Zasadzinski JA
中科院分区：
文献类型：
--
作者：
Dhar P;Cao Y;Fischer TM;Zasadzinski JA
300 nm 直径棒的磁力驱动旋转显示，空气-水界面处白蛋白的表面粘度在两个小时内从 10−9 Ns/m 增加到 10−5 Ns/m，而表面压力在几分钟内饱和。表面粘度的增加并不伴随着弹性的相应增加，这表明蛋白质膜随着时间的推移而退火，形成更致密的膜，从而导致抗剪切力增加。棒的纳米尺寸提供了与被动微流变学相同的灵敏度，并提高了测量更粘稠薄膜的能力。
The magnetically driven rotation of 300 nm diameter rods shows the surface viscosity of albumin at an air-water interface increases from 10−9 to 10−5 Ns/m over two hours while the surface pressure saturates in minutes. The increase in surface viscosity is not accompanied by a corresponding increase in elasticity, suggesting that the protein film anneals with time, resulting in a more densely packed film leading to increased resistance to shear. The nanometer dimensions of the rods provide the same sensitivity as passive microrheology with an improved ability to measure more viscous films.