Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4
Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4
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DOI：
10.1593/neo.03427
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发表时间：
2004-05-01
期刊：
影响因子：
4.8
通讯作者：
Yu, JS
中科院分区：
文献类型：
--
作者：
Ehtesham, M;Yuan, XP;Yu, JS
恶性神经胶质瘤产生播散性微卫星，其在很大程度上对目前采用的疗法是难治的，导致最终的肿瘤复发和死亡。使用肿瘤嗜性神经干细胞（NSC）作为治疗性基因产物的递送载体代表了一种有吸引力的策略，特别是专注于治疗这些残留的肿瘤病灶。我们希望阐明神经干细胞对胶质瘤嗜性的生物学线索。在这种情况下，我们描述了肿瘤嗜性神经干细胞主要包括表达趋化因子受体4（CXCR4）的星形胶质细胞祖细胞。阻断CXCR4可显著抑制NSC向肿瘤的迁移。这些发现定义了与移植的神经干细胞内的细胞群相关的特定特征，这些细胞群表现出神经胶质瘤追踪行为。
Malignant gliomas spawn disseminated microsatellites, which are largely refractory to currently employed therapies, resulting in eventual tumor recurrence and death. The use of tumor-tropic neural stem cells (NSCs) as delivery vehicles for therapeutic gene products represents an attractive strategy specifically focused at treating these residual neoplastic foci. We wished to elucidate the biological cues governing NSC tropism for glioma. In this context, we describe that tumor-tropic NSCs comprise largely of astrocytic progenitors expressing chemokine receptor 4 (CXCR4). Blocking of CXCR4 significantly inhibits NSC migration toward the tumor. These findings define specific characteristics associated with the cell populations within transplanted NSCs that demonstrate glioma-tracking behavior.