Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K)/Akt Pathway
Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K)/Akt Pathway
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DOI：
10.1254/jphs.10185sc
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发表时间：
2011-01-01
影响因子：
3.5
通讯作者：
Kai, Hirofumi
中科院分区：
文献类型：
--
作者：
Yano, Shuichiro;Morino-Koga, Saori;Kai, Hirofumi
胰岛素激活Akt通过磷脂酰肌醇-3-OH激酶（PI-3 K）传递，并增强葡萄糖摄取。PI-3 K/Akt信号在胰岛素抵抗中减弱。因此，激活PI-3 K/Akt信号传导导致葡萄糖摄取改善的方法可以改善高血糖症。在这里，我们发现，低强度电流或温和的电刺激（MES）激活PI-3 K/Akt信号，并增加大鼠骨骼肌（L 6）细胞的葡萄糖摄取。MES增强了肌细胞（参与葡萄糖处置的主要细胞）中的葡萄糖摄取，表明MES可能对高血糖症有可能的有益作用。
Activation of Akt by insulin is transmitted via phosphatidylinositol-3-OH kinase (PI-3K) and enhances glucose uptake. The PI-3K/Akt signaling is diminished in insulin resistance. Thus, approaches that activate PI-3K/Akt signaling leading to improved glucose uptake may ameliorate hyperglycemia. Here we showed that low-intensity electrical current or mild electrical stimulation (MES) activated the PI-3K/Akt signaling and increased the glucose uptake in rat skeletal muscle (L6) cells. The glucose uptake enhanced by MES in muscle cells, the major cells involved in glucose disposal, suggests MES may have a possible beneficial effect on hyperglycemia.