Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
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DOI：
10.4269/ajtmh.2003.68.16
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发表时间：
2003-04-01
影响因子：
3.3
通讯作者：
Hawley, WA
中科院分区：
文献类型：
--
作者：
Gimnig, JE;Vulule, JM;Hawley, WA
作为肯尼亚西部一项大规模随机对照试验的一部分，研究了经氯菊酯处理的蚊帐 (ITN) 对疟疾病媒的影响。饲养的冈比亚按蚊的室内静息密度和安。与对照鸡舍相比，干预鸡舍的毛内毛虫分别降低了 58.5% (P = 0.010) 和 94.5% (P = 0.001)。 An 子孢子感染率。冈比亚有限公司干预区的子孢子感染率为 0.8%，而对照区为 3.4%（P = 0.026）。 funestus 在两个区域之间没有显着差异。我们估计干预地区恶性疟原虫的总体传播率比对照地区低 90%。研究期间未检测到氯菊酯耐药性。通过 An 的密度来测量。冈比亚有限公司指出，如果一名或多名居民没有在蚊帐下睡觉或六个月内未对蚊帐进行重新处理，蚊帐的功效就会降低。这些结果表明，如果每晚使用且至少每半年重新使用氯菊酯一次，驱虫蚊帐的效果最佳。
The effect of permethrin-treated bed nets (ITNs) on malaria vectors was studied as part of a large-scale, randomized, controlled trial in western Kenya. Indoor resting densities of fed Anopheles gambiae s.l. and An. funestus in intervention houses were 58.5% (P = 0.010) and 94.5% (P = 0.001) lower, respectively, compared with control houses. The sporozoite infection rate in An. gambiae s.l. was 0.8% in intervention areas compared with 3.4% (P = 0.026) in control areas, while the sporozoite infection rates in An. funestus were not significantly different between the two areas. We estimated the overall transmission of Plasmodium falciparum in intervention areas to be 90% lower than in control areas. Permethrin resistance was not detected during the study period. As measured by densities of An. gambiae s.l., the efficacy of bed nets decreased if one or more residents did not sleep under a net or if bed nets had not been re-treated within six months. These results indicate that ITNs are optimally effective if used every night and if permethrin is reapplied at least biannually.