Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications
Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications
复制标题
纳米级混合涂层使多功能组织支架能够用于潜在的多模式治疗应用
DOI：
10.1021/acsami.9b04278
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发表时间：
2019-07-31
影响因子：
9.5
通讯作者：
Sun, Dan
中科院分区：
文献类型：
--
作者：
Guo, Zhijun;Jiang, Nan;Sun, Dan
通过自然启发的逐层组装过程，我们开发了一种独特的多功能组织支架，该支架由多孔聚氨酯基底和纳米级壳聚糖/氧化石墨烯混合涂层组成。载药壳聚糖和氧化石墨烯纳米片的替代层通过强静电相互作用保持在一起，产生了一个强大的多层结构，可以控制纳米级的结构元素取向和化学组成。我们的支架系统实现了多种治疗剂和光热治疗的组合pH控制共递送。新的平台技术可以推广到生产其他组织支架系统，并可能实现潜在的多模式治疗应用，如骨癌管理。
Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.