Polymersome Wound Dressing Spray Capable of Bacterial Inhibition and H2S Generation for Complete Diabetic Wound Healing
Polymersome Wound Dressing Spray Capable of Bacterial Inhibition and H2S Generation for Complete Diabetic Wound Healing
复制标题
聚合物伤口敷料喷雾能够抑制细菌并产生 H2S，促进糖尿病伤口完全愈合
DOI：
10.1021/acs.chemmater.1c01872
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发表时间：
2021-10-12
影响因子：
8.6
通讯作者：
Du, Jianzhong
中科院分区：
文献类型：
--
作者：
Liu, Danqing;Liao, Yuyao;Du, Jianzhong
糖尿病创面由于反复的细菌感染、增殖减少以及表皮和内皮细胞的迁移而难以愈合。这与糖尿病患者白细胞功能受损和血液中硫化氢浓度低有关。在此，一种以抗菌聚合物为基础的创面敷料喷雾被证明可用于糖尿病伤口的完全愈合。所设计的聚合体是由poly(epsilon-caprolactone)(24)-block-poly[lysine(15)-stat-(S-aroylthiooxime)(23)][PCL24-b-P(Lys(23)-Stat-Sato(15))]自组装而成的，其中Pcl为疏水成膜块，P(Lys-Stat-Sato)为亲水稳定剂。由于抗菌剂P(Lys(23)-Stat-Sato(15))阻断剂诱导的静电相互作用，聚合体能够穿透并杀灭革兰氏阳性和革兰氏阴性细菌。此外，Sato片段能够通过与半胱氨酸反应(长达12小时)长期生成硫化氢。这促进了表皮和内皮细胞的增殖、迁移和血管生成。总体而言，这种以多聚体为基础的创面敷料喷雾作为细菌抑制剂和硫化氢生成器，为糖尿病伤口的有效治疗提供了新的见解。
Diabetic wounds are difficult to heal due to recurrent bacterial infection, decreased proliferation, and migration of epidermal and endothelial cells. This is related to impaired leukocyte function and low blood concentrations of H2S in diabetic patients. Herein, an antibacterial polymersome-based wound dressing spray was demonstrated for complete diabetic wound healing. The designed polymersome was self-assembled from poly(epsilon-caprolactone)(24)-block-poly[lysine(15)-stat-(S-aroylthiooxime)(23)] [PCL24-b-P(Lys(23)-stat-SATO(15))], where PCL is the hydrophobic membrane-forming block and P(Lys-stat-SATO) acts as a hydrophilic stabilizer block. The polymersomes can penetrate and kill Gram-positive and Gram-negative bacteria because of the electrostatic interaction induced by the antibacterial P(Lys(23)-stat-SATO(15)) block. Furthermore, the SATO segments are capable of long-term H2S generation by reacting with cysteine (up to 12 h). This promotes proliferation, migration of epidermal and endothelial cells, and angiogenesis. Overall, this polymersome-based wound dressing spray acts as a bacterial inhibitor and H2S generator and offers a fresh insight into the effective treatment of diabetic wounds.