Enantioselective addition of terminal alkynes to aldehydes catalyzed by a Cu(I)-TRAP complex
Enantioselective addition of terminal alkynes to aldehydes catalyzed by a Cu(I)-TRAP complex
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DOI：
10.1021/ol701534n
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发表时间：
2007-09-27
期刊：
影响因子：
5.2
通讯作者：
Sawamura, Masaya
中科院分区：
文献类型：
--
作者：
Asano, Yohsuke;Hara, Kenji;Sawamura, Masaya
在Cu（O-t-Bu）与TRAP手性双膦原位合成的Cu-膦配合物存在下，芳香醛与末端炔的加成反应在温和的条件下进行，得到了对映体富集的炔丙醇.此外，根据化学计量反应，该反应可能涉及TRAP配位的Cu（I）乙炔化物与醛的加成。
The addition of terminal alkynes to aromatic aldehydes was carried out under mild conditions in the presence of a Cu-phosphine complex, which was prepared in situ from Cu(O-t-Bu) and TRAP chiral bisphosphine, to yield enantiomerically enriched propargyl alcohols with moderate enantioselectivities. Furthermore, according to stoichiometric reactions, the reaction presumably involves the addition of a TRAP-coordinated Cu(l) acetylide to an aldehyde.